[Lab notes from a vaccine trial at Sioux Falls Army Air Field]
During World War II Heidelberger served as a member of the Pneumonia Commission established by the Board for the Investigation
and Control of Influenza and Other Infectious Diseases (later the Army Epidemiological Board) under the Surgeon General of
the U.S. Army. The Commission, headed by Colin MacLeod (whose name appears on the first page of these immunization records),
a microbiologist and co-discoverer of the genetic properties of DNA, organized a trial of a vaccine against pneumococcal pneumonia
developed by Heidelberger. The trial, carried out among 20,000 trainees at an air base in Sioux Falls, South Dakota, proved
that a vaccine made from a mixture of purified capsular polysaccharides from four different types of pneumococcus (types I,
II, V, and VII) provided effective protection against pneumonia when compared with a control group which received saline solution,
and which had a higher incidence of the disease.
Item is handwritten.
Number of Image Pages:
3 (273,909 Bytes)
This item is in the public domain. It may be used without permission.
Medical Subject Headings (MeSH):
Antigens and Antibodies: Heidelberger and The Rise of Quantitative Immunochemistry, 1928-1954
Letter from Richard G. Hodges, United States Army Air Forces to Michael Heidelberger (November 3, 1944)
Letter from Richard G. Hodges, United States Army Air Forces to Michael Heidelberger (January 2, 1945)
Letter from Michael Heidelberger to Richard G. Hodges, United States Army Air Forces (January 18, 1945)