In this letter Linus Pauling, the world's preeminent physical chemist at the time, asked Heidelberger to comment on a
hypothesis regarding the chemical structure of antibodies and the location of the sites at which they bind to antigens Pauling
had developed. Pauling's article was published as "A Theory of the Structure and Process of Formation of Antibodies"
in the Journal of the American Chemical Society 62 (1940), pp. 2643-2657.
Number of Image Pages:
1 (34,277 Bytes)
1940-06-21 (June 21, 1940)
Reproduced with permission of Oregon State University Library, Ava Helen and Linus Pauling Papers.
Medical Subject Headings (MeSH):
Antigens and Antibodies: Heidelberger and The Rise of Quantitative Immunochemistry, 1928-1954
Letter from Linus Pauling to Michael Heidelberger (April 3, 1940)
Letter from Michael Heidelberger to Linus Pauling (July 1, 1940)
A Theory of the Structure and Process of Formation of Antibodies (July 27, 1940) (in The Linus Pauling Papers)
I am sending enclosed my manuscript on the structure and properties of antibodies. I would be glad to have your opinion of
the manuscript, and especially any suggestions about its improvement. The manuscript has been submitted to Lamb for publication
in the Journal of the American Chemical Society, with the suggestion that I might want to revise it somewhat before publication.