Throughout Heidelberger's career, fellow scientists, including the preeminent physical chemist Linus Pauling, turned to
him to obtain preparations of polysaccharide antigens, antisera, or purified antibodies for use in their own experiments.
Heidelberger accumulated an extensive stock of these substances over the course of six decades of research in immunochemistry.
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1942-09-28 (September 28, 1942)
Reproduced with permission of Oregon State University Library, Ava Helen and Linus Pauling Papers.
Medical Subject Headings (MeSH):
Antigens and Antibodies: Heidelberger and The Rise of Quantitative Immunochemistry, 1928-1954
Letter from Michael Heidelberger to Linus Pauling (October 2, 1942)
In the course of the pleasant evening that we spent with you at the Mirsky's home, I mentioned that Dr. Campbell had
carried out mouse protection tests with a synthetic anti-pneumonia serum Type I. The results were satisfactory, but it is
my feeling that the work should be repeated, perhaps on a somewhat larger scale in order to provide a definite check. The
original work was done with use as starting material of a few tenths gram of Type I polysaccharide prepared by Dr. Wright,
a student of Campbell's. On reaching my laboratory I now find that our plans for having a larger amount of this polysaccharide
prepared have been held up, partially because of the war program in the laboratory. I am writing to ask you if you have a
supply of Type I polysaccharide on hand, and could give us some of this material, possibly as much as a gram. This would
speed up our work very much indeed, and we would be very grateful to you if you could provide us with this material.
The only further progress which has been made in our program is that Campbell has found that, in addition to fibrinogen, ovalbumin
also works satisfactorily as an antigen for the preparation of artificial antibodies.