Letter from Michael Heidelberger to Kai O. Pedersen
In this letter Heidelberger followed up on his visit to the laboratory of Arne Tiselius at the University of Uppsala in the
summer of 1934, during which he used ultracentrifugation to determine the size of antibodies molecules. Tiselius was the
inventor of the ultracentrifuge, and Uppsala was the first university to build one, in a separate building designed to withstand
the vibrations caused by the earliest models.
Number of Image Pages:
1 (64,683 Bytes)
1934-11-30 (November 30, 1934)
Pedersen, Kai O.
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Medical Subject Headings (MeSH):
Antigens and Antibodies: Heidelberger and The Rise of Quantitative Immunochemistry, 1928-1954
I was very much interested in the numerous matters in your letter, and only hope that the things I left still to be done did
not prove to be a great burden to you. By this time you have certainly received the manuscript and that will save you the
trouble of going over things twice. I am sorry that the new equilibrium runs showed a drift and I hope it was not great enough
to weaken the value of our findings. Is there any way of estimating the amount of material of smaller and larger molecular
I have read Doctor Hamilton's letter and think it might be interesting as a check to try a run on fat-free material as
long as come has been offered. I do not think our preparations contained appreciable amounts of lipoid for we first shook
the extract with toluene and then took out an acid precipitable fraction which would remove still more lipoid. I think the
chief impurity likely to be up to 2 or 3 per cent of serum globulin. Would that be sufficient foraccount for the drift which
I am glad that we escaped so much rain, but regret that I could not help you with some of the things that still remained to
With cordial greetings from us to you and Mrs. Pedersen,