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The Michael Heidelberger Papers

Letter from Michael Heidelberger to Kai O. Pedersen pdf (64,683 Bytes) transcript of pdf
Letter from Michael Heidelberger to Kai O. Pedersen
In this letter Heidelberger followed up on his visit to the laboratory of Arne Tiselius at the University of Uppsala in the summer of 1934, during which he used ultracentrifugation to determine the size of antibodies molecules. Tiselius was the inventor of the ultracentrifuge, and Uppsala was the first university to build one, in a separate building designed to withstand the vibrations caused by the earliest models.
Number of Image Pages:
1 (64,683 Bytes)
1934-11-30 (November 30, 1934)
Heidelberger, Michael
Pedersen, Kai O.
This item is in the public domain. It may be used without permission.
Medical Subject Headings (MeSH):
Exhibit Category:
Antigens and Antibodies: Heidelberger and The Rise of Quantitative Immunochemistry, 1928-1954
Box Number: 5
Folder Number: 9
Unique Identifier:
Document Type:
Letters (correspondence)
Physical Condition:
Folder: MS C 245 (first finding aid)
November 30, 1934
Dear Doctor Pedersen
I was very much interested in the numerous matters in your letter, and only hope that the things I left still to be done did not prove to be a great burden to you. By this time you have certainly received the manuscript and that will save you the trouble of going over things twice. I am sorry that the new equilibrium runs showed a drift and I hope it was not great enough to weaken the value of our findings. Is there any way of estimating the amount of material of smaller and larger molecular size?
I have read Doctor Hamilton's letter and think it might be interesting as a check to try a run on fat-free material as long as come has been offered. I do not think our preparations contained appreciable amounts of lipoid for we first shook the extract with toluene and then took out an acid precipitable fraction which would remove still more lipoid. I think the chief impurity likely to be up to 2 or 3 per cent of serum globulin. Would that be sufficient foraccount for the drift which you observed?
I am glad that we escaped so much rain, but regret that I could not help you with some of the things that still remained to be done.
With cordial greetings from us to you and Mrs. Pedersen,
Michael Heidelberger
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