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The Michael Heidelberger Papers

Title:
Letter from Florence R. Sabin to Michael Heidelberger pdf (156,786 Bytes) transcript of pdf
Letter from Florence R. Sabin to Michael Heidelberger
Description:
During the 1930s the anatomist and cell biologist Florence R. Sabin (1871-1953), the first woman to be elected to membership in the National Academy of Sciences, had investigated how antibodies were formed in response to foreign substances, using a new protein-bound red dye developed by Heidelberger as a tracer antigen. In this letter Sabin congratulated Heidelberger on the "wonderful field of further experimentation your quantitative methods have opened up," and suggested that multivalent antibodies emerge from simpler, univalent ones.
Item is handwritten.
Number of Image Pages:
6 (156,786 Bytes)
Date:
1941-10-24 (October 24, 1941)
Creator:
[Sabin, Florence R.]
Recipient:
Heidelberger, Michael
Rights:
Reproduced with permission of Geraldine F. Swan.
Subject:
Medical Subject Headings (MeSH):
Antigen-Antibody Reactions
Exhibit Category:
Antigens and Antibodies: Heidelberger and The Rise of Quantitative Immunochemistry, 1928-1954
Box Number: 5
Folder Number: 14
Unique Identifier:
DHBBNY
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Folder: MS C 245 (first finding aid)
Transcript:
Oct. 24-41
Dear Michael,
At last I have had time to read and study your wonderful papers. Of course I don't grasp all of the work [...] what I do get seems [...] a thrilling story.
I want to ask you one or two questions (1) Is it not true that Paulings idea was of a very simply -- physical -- change from normal U antibodies globulin --just-
[END PAGE ONE]
[BEGIN PAGE TWO]
a bending at the two ends of a chain -- whereas your concept involves a more fundamental chemical change at several points in the molecule (2) Doesn't your concept stress more than ever the element of time necessary for the cells to elaborate -- the multivalent effection antibodies -- that is to say the low grade--[...]-- antibody [...] be the first
[END PAGE TWO]
[BEGIN PAGE THREE]
attempt of the cell and the multivalent the further evolution of the process. (3) Does the presence of actin complement [. . .] a more effective antigen-antibody reaction -- that is [. . .] a physiological part of the mechanism -- or just a [. . .] These will all seem pretty stupid questions to you -- at any rate I seem vaguely [. . .] what a wonderful field for future
[END PAGE THREE]
[BEGIN PAGE FOUR]
experimentation your quantitative methods have opened up. Isn't "Fess" perfectly [. . .]?
I have been asked by the Medical [. . .] here to give a little talk about the cellular [. . .]. If the work -- and I am in [. . .] whether I [. . .] or not -- and if I do whether I wait until I have been East again and [. . .] things over with you. I shall be in as usual in January for [. . .]and [. . .] Guggenheim once more. I [. . .] this year
[END PAGE FOUR]
[BEGIN PAGE FIVE]
[. . .] since she is in New York instead of me.
I keep on agonizing [. . .] with short intervals of respite -- for [. . .] cannot keep up the tension [. . .] It was pretty bad a few days when it seemed as if Moscow was to fall soon -- but now the Russians seem to be holding up and [. . .] will soon help. I have very great
[END PAGE FIVE]
[BEGIN PAGE SIX]
Faith in the English [. . .] rear this new collection of Hitler's addresses. I think it's more important from the standpoint of understanding him [. . .] Mein Kampff. I [. . .] when [. . .] book is coming out.
I hope that Hanna is quite well again and send her [. . .] my love.
With many thanks
Florence
Metadata Last Modified Date:
2011-04-15
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