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The Maxine Singer Papers

Title:
Letter from Maxine Singer to James D. Watson pdf (47,168 Bytes) transcript of pdf
Letter from Maxine Singer to James D. Watson
Number of Image Pages:
1 (47,168 Bytes)
Date:
1964-12-04 (December 4, 1964)
Creator:
Singer, Maxine
Recipient:
Watson, James D.
Harvard University. The Biological Laboratories
Source:
Original Repository: Library of Congress. Maxine Singer Papers
Rights:
Reproduced with permission of the Library of Congress.
Subject:
Medical Subject Headings (MeSH):
Ribonucleases
Exhibit Category:
Nucleic Acids, the Genetic Code, and Transposable Genetic Elements: A Life in Research
Box Number: 2
Folder Number: 1
Unique Identifier:
DJBBBV
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Correspondence, 1955-2004, n.d.
SubSeries: Chronological
Folder: 1964
Transcript:
December 4, 1964
Dear Dr. Watson:
Leon Heppel recently spent some time at Rockefeller with Zinder. Upon his return, Zinder gave him a slant of your ribonuclease--minus mutant (127?). Both Leon and I would very much like to do some experiments with this organism. However, because we did not obtain the mutant directly from you, we would first like to be sure that our general plans in no way conflict with your own. If you have any objections to our use of the organism, would you please let us know.
In general, Leon is interested in using the mutant to extend his recent studies on enzymes that appear to be active on the surface of the cell. In this connection he is also using the ribonuclease--minus mutant MRE-600, which was kindly sent to him by Wade in England.
For my part, I am interested in looking at the activity of the soluble RNA-specific phosphodiesterase, in cells that lack the "ribosomal" ribonuclease. We already know that in MRE-600 neither diesterase nor polynucleotide phosphorylase activity is increased.
I am enclosing a few pertinent reprints.
With kindest regards,
Sincerely yours,
Maxine Singer
Metadata Last Modified Date:
2010-12-06
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