Thanks a lot for your two letters. The time for the October lecture is quite suitable. It looks like an interesting program
and I look forward to participating. It would probably do me a lot of good to listen to the other talks of the series but
I couldn't afford the time.
As usual, my spirits are up and things go well at this season of the year, whereas in mid winter and in March everything is
terrible. The mood swings, and swings in productivity, really oscillate violently in Ithaca -- much more so than in Washington.
Other people are also affected -- its even mentioned in the newspapers. People are morose, cheerless and generally low from
about Jan 15, when Christmas cheer has worn off until about April 1. March is an especially difficult month. Ithaca is so
lovely in the spring, summer and fall and so awful in the winter! In addition to the depression, it's terribly annoying
to have one's productivity fall off for a 2 -- 2 1/2 month period, -- because one has to work so much harder to catch
up in the spring.
I'm glad that you enjoyed your stay
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in India. Debi Burma is such a nice person!
I have a very good graduate student now, Joel Weiner, and it's a pleasure to see him perform. We've thought of looking
at fluorescence changes in binding proteins, especially since Harold Edelhoch was around. Joel, on his own initiative, carried
out a nice study showing that glutamine binding fluorescence is reduced and the peak shifted to lower wave length by the substrate,
glutamine. Then he collaborated with Quentin Gibson to show that the rate constant for association is 6*10^7 M^-1 sec^-1
and the off mart[?] in is 10 per second. The "on" rate is very fast but not so fast that it's only diffusion
controlled. Some minute time elapses while the glutamine looks for the specific slot on the binding protein with which it
interacts. It's fun to watch Gibson at work. His office--lab is a mad scientist affair with stuff scatter all over and
electronic gear everywhere. He has a compute going click -- click -- click forever and junk to the ceiling. But in less
than an hour he ran a complete investigation with stop-flow kinetics, 1/2 time curves revealed on the oscilloscope and analyzed
with high accuracy by the computer. It's marvelous!
David and Monica both work near you this summer -- Monica in Lib. of Medicine typing and David in Costop for Child Development
Inst. on Cordell Ave. Maybe you'll get to see my dirty grand daughter -- now eighteen months. She gave both Adelaide
and me a dreadful summer cold by coming in the house with serious exhudate running in a steady stream down out of her nose,
into her mouth and all over everything.