This fourth chart compares the differences between ATP and GTP in dissociating pre-bound glucagon from a liver membrane cell
receptor. As one can see by the charted lines in the upper right hand corner of the page, a smaller concentration of GTP could
dissociate what a much larger concentration of ATP could accomplish in the same period of time. From these experiments, Rodbell
concluded that, of all the nucleotides, GTP was the most effective biological catalyst.
Item is handwritten.
Number of Image Pages:
1 (227,938 Bytes)
ca. January 1970
Courtesy of Fernando Ribeiro-Neto.
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Medical Subject Headings (MeSH):
Signal Transduction and the Discovery of G-Proteins, 1969-1980
Influence of Additions on Glucagon Binding (December 27, 1969)