GTP Stimulates and Inhibits Adenylate Cyclase in Fat Cell Membranes through Distinct Regulatory Processes
The first of two articles in which Rodbell indicated that in addition to transducing hormone signals across the membrane,
the G-protein could also inhibit signaling at the discriminator point. He provided evidence that G-proteins at the cellular
receptors were sophisticated enough to both inhibit and activate signal transduction.
Number of Image Pages:
3 (400,901 Bytes)
1977-11-25 (November 25, 1977)
Lad, Pramod M.
Periodical: Yamamura, Hirohei, Pramod M. Lad, and Martin Rodbell. "GTP Stimulates and Inhibits Adenylate Cyclase in Fat Cell Membranes
through Distinct Regulatory Processes." Journal of Biological Chemistry 252, 22 (25 November 1977): 7964-7966. Article.
American Society for Biochemistry and Molecular Biology
Reproduced with permission of the American Society for Biochemistry and Molecular Biology.
Medical Subject Headings (MeSH):
Signal Transduction and the Discovery of G-Proteins, 1969-1980
Letter from Joshua Lederberg to Michael Doudoroff (November 22, 1948) (in The Joshua Lederberg Papers)