Studies on Sympathomimetic Amines. I. The Biotransformation and Physiological Disposition of l-Ephedrine and l-Norephedrine
This article was the first in a series of papers by Axelrod on the role played in the body by sympathetic amines, a broad
class of chemicals that mimic the actions of the sympathetic nervous system and have an amine basic structure. Through a
variety of tests on several animals, Axelrod found two primary processes, demethylation and hydroxylation, that metabolically
transformed ephedrine. He also noted that various animal species showed considerable differences in the relative importance
of the two metabolic routes.
Number of Image Pages:
12 (1,063,369 Bytes)
1953-09 (September 1953)
Periodical: Axelrod, Julius. "Studies on Sympathomimetic Amines. I. The Biotransformation and Physiological Disposition of l-Ephedrine
and l-Norephedrine." Journal of Pharmacology and Experimental Therapeutics 109, 1 (September 1953): 62-73. Article. 12
American Society for Pharmacology and Experimental Therapeutics
Reproduced with permission of the American Society for Pharmacology and Experimental Therapeutics.