Studies on Sympathomimetic Amines. II. The Biotransformation and Physiological Disposition of D-Amphetamine, D-P-Hydroxyamphetamine
In this second in a series of papers by Axelrod on the role played in the body by sympathetic amines, a broad class of chemicals
that mimic the actions of the sympathetic nervous system and have an amine basic structure, Axelrod found that the fate and
physiological disposition of compounds of amphetamine in several species of animals was metabolized by a number of biochemical
processes, including hydroxylation, demethylation, deamination, and conjugation. Axelrod again determined that various species
showed considerable variations in the ways in which their bodies transformed these drugs.
Number of Image Pages:
13 (1,146,989 Bytes)
1954-03 (March 1954)
Periodical: Axelrod, Julius. "Studies on Sympathomimetic Amines. II. The Biotransformation and Physiological Disposition of D-Amphetamine,
D-P-Hydroxyamphetamine and D-Methamphetamine." Journal of Pharmacology and Experimental Therapeutics 110, 3 (March 1954):
315-326. Article. 13 Images.
American Society for Pharmacology and Experimental Therapeutics
Reproduced with permission of the American Society for Pharmacology and Experimental Therapeutics.