The Enzymatic Deamination of Amphetamine (Benzedrine)
Part of long series of research articles on the role played in the body by sympathetic amines, in this paper, Axelrod compared
the transformation of amphetamine in rabbits to rats, dogs, and guinea pigs. The subject of the article originated in Axelrod's
curiosity as to why when amphetamine was administered to rabbits it disappeared entirely. Axelrod found in this article that
one or several enzymes in a rabbit's liver deaminated amphetamine, leading to the formation of phenylacetone and ammonia.
He also determined that ephedrine was similarly demethylated to norephedrine and formaldehyde by the microsomal drug metabolizing
Number of Image Pages:
12 (987,525 Bytes)
1955-06 (June 1955)
Periodical: Axelrod, Julius. "The Enzymatic Deamination of Amphetamine (Benzedrine)." Journal of Biological Chemistry 214, 2 (June
1955): 753-763. Article. 12 Images.
American Society for Biochemistry and Molecular Biology
Reproduced with permission of the American Society for Biochemistry and Molecular Biology.
Medical Subject Headings (MeSH):
Work on the Sympathomimetic Amines, 1946-1958
Studies on Sympathomimetic Amines. I. The Biotransformation and Physiological Disposition of l-Ephedrine and l-Norephedrine
Studies on Sympathomimetic Amines. II. The Biotransformation and Physiological Disposition of D-Amphetamine, D-P-Hydroxyamphetamine
and D-Methamphetamine (March 1954)