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The Julius Axelrod Papers

Title:
The Enzymatic Deamination of Amphetamine (Benzedrine) pdf (987,525 Bytes) ocr (27,459 Bytes)
The Enzymatic Deamination of Amphetamine (Benzedrine)
Description:
Part of long series of research articles on the role played in the body by sympathetic amines, in this paper, Axelrod compared the transformation of amphetamine in rabbits to rats, dogs, and guinea pigs. The subject of the article originated in Axelrod's curiosity as to why when amphetamine was administered to rabbits it disappeared entirely. Axelrod found in this article that one or several enzymes in a rabbit's liver deaminated amphetamine, leading to the formation of phenylacetone and ammonia. He also determined that ephedrine was similarly demethylated to norephedrine and formaldehyde by the microsomal drug metabolizing enzymes.
Number of Image Pages:
12 (987,525 Bytes)
Date:
1955-06 (June 1955)
Creator:
Axelrod, Julius
Source:
Periodical: Axelrod, Julius. "The Enzymatic Deamination of Amphetamine (Benzedrine)." Journal of Biological Chemistry 214, 2 (June 1955): 753-763. Article. 12 Images.
Publisher:
American Society for Biochemistry and Molecular Biology
Rights:
Reproduced with permission of the American Society for Biochemistry and Molecular Biology.
Subject:
Medical Subject Headings (MeSH):
Microsomes
Amphetamine
Deamination
Exhibit Category:
Work on the Sympathomimetic Amines, 1946-1958
Relation:
Metadata Record Studies on Sympathomimetic Amines. I. The Biotransformation and Physiological Disposition of l-Ephedrine and l-Norephedrine (September 1953) pdf (1,063,369 Bytes) ocr (31,065 Bytes)
/ps/access/HHAAAG.pdf
Metadata Record Studies on Sympathomimetic Amines. II. The Biotransformation and Physiological Disposition of D-Amphetamine, D-P-Hydroxyamphetamine and D-Methamphetamine (March 1954) pdf (1,146,989 Bytes) ocr (32,431 Bytes)
/ps/access/HHAAAH.pdf
Box Number: 22
Folder Number: 7
Unique Identifier:
HHAAAI
Document Type:
Articles
Language:
English
Format:
application/pdf
image/tif
Series: Writings and Publications, 1910-2003
SubSeries: Articles by Axelrod
SubSubSeries: Loose Reprints
Folder: Articles 1-280, 1948-1969
Metadata Last Modified Date:
2016-05-26
Linked Data:
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