While working on the metabolism of narcotic drugs, Axelrod observed that repeated administration of drugs produced tolerance
to the drugs, but also reduced the body's ability to demethylate them enzymatically. In this article, he proposed a mechanism
for tolerance to narcotic drugs. According to Axelrod, his hypothesis--that the continuous interaction of narcotic drugs
with the demethylating enzymes deactivated the enzymes and possibly even the receptors of narcotic drugs, thus decreasing
the subject's response to narcotic drugs--stimulated considerable criticism from some of his colleagues.
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1956-08-10 (August 10, 1956)
Periodical: Axelrod, Julius. "Possible Mechanism of Tolerance to Narcotic Drugs." Science 124, (10 August 1956): 263-264. Article.
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