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The Julius Axelrod Papers

Title:
Possible Mechanism of Tolerance to Narcotic Drugs pdf (189,400 Bytes) ocr (7,163 Bytes)
Possible Mechanism of Tolerance to Narcotic Drugs
Description:
While working on the metabolism of narcotic drugs, Axelrod observed that repeated administration of drugs produced tolerance to the drugs, but also reduced the body's ability to demethylate them enzymatically. In this article, he proposed a mechanism for tolerance to narcotic drugs. According to Axelrod, his hypothesis--that the continuous interaction of narcotic drugs with the demethylating enzymes deactivated the enzymes and possibly even the receptors of narcotic drugs, thus decreasing the subject's response to narcotic drugs--stimulated considerable criticism from some of his colleagues.
Number of Image Pages:
2 (189,400 Bytes)
Date:
1956-08-10 (August 10, 1956)
Creator:
Axelrod, Julius
Source:
Periodical: Axelrod, Julius. "Possible Mechanism of Tolerance to Narcotic Drugs." Science 124, (10 August 1956): 263-264. Article. 2 Images.
Publisher:
American Association for the Advancement of Science
Rights:
Reproduced with permission from the American Association for the Advancement of Science. Readers may view, browse, and/or download this material for temporary copying purposes only, provided these uses are for noncommercial personal purposes. Except as provided by law, this material may not be further reproduced, distributed, transmitted, modified, adapted, performed, displayed, published, or sold in whole or in part, without prior written permission from AAAS.
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Subject:
Medical Subject Headings (MeSH):
Drug Tolerance
Narcotics
Exhibit Category:
Work on the Sympathomimetic Amines, 1946-1958
Box Number: 22
Folder Number: 9
Unique Identifier:
HHAAAJ
Document Type:
Articles
Language:
English
Format:
application/pdf
image/tif
Series: Writings and Publications, 1910-2003
SubSeries: Articles by Axelrod
SubSubSeries: Loose Reprints
Folder: Articles 1-280, 1948-1969
Metadata Last Modified Date:
2006-07-19
Linked Data:
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