RNA Codewords and Protein Synthesis, II. Nucleotide Sequence of a Valine RNA Codeword
After the poly-U experiments, the next major challenge was finding out what the remaining codewords were. In this article,
the authors use a rapid method for measuring sRNA binding to ribosomes and try to resolve some problems with ambiguous and
synonymous codewords. The experimental evidence suggests the binding of specific types of sRNA to ribosomes is directed by
only certain corresponding trinucleotides, making sequencing efforts more feasible in the coding process.
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Nirenberg, Marshall W.
Periodical: Leder, Philip, and Marshall W. Nirenberg. "RNA Codewords and Protein Synthesis, II. Nucleotide Sequence of a Valine RNA
Codeword." Proceedings of the National Academy of Sciences of the United States of America 52, (1964): 420-427. Article.
National Academy of Sciences (U.S.)
Reproduced with permission of Marshall W. Nirenberg.
Medical Subject Headings (MeSH):
Translating the Code of Life and the Nobel Prize, 1962-1968