In this letter to Dr. G. Schramm of the Max Planck Institute, Nirenberg requests information regarding the use of German-produced
synthetic deoxypolynucleotides in his enzymatic investigations. Enclosing reprints of his previous articles, Nirenberg suggests
that their collaboration could yield quick results in the study of protein synthesis crucial to deciphering the genetic code.
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1961-11-22 (November 22, 1961)
Nirenberg, Marshall W.
Max-Planck-Institut fur Virusforschung
Reproduced with permission of Marshall W. Nirenberg.
Medical Subject Headings (MeSH):
Synthetic RNA and the Poly-U Experiments, 1959-1962
I read your synthetic procedure for obtaining deoxypolynucleotides with great interest. I very much would like to get or
make 2 to 5 mg of deoxypoly A, deoxypoly T, deoxypoly C, deoxypoly G, and also mixed polymers. I am interested primarily
in cell-free protein synthesis from an enzymatic point of view. Recently we found that polyribo U served as a synthetic messenger
RNA which directed the synthesis of polyphenylalanine in a cell-free system. I am enclosing reprints of this work which describe
these experiments in detail. I would like to use the deoxypolynucleotides in this work for I feel certain that some will
work in our enzymatic system. I would be glad to collaborate with you, if you would like to, on aspects of our work dealing
with these polymers. Certainly they would have a great deal of potential in our cell-free system. Such a collaborative effort
could yield important results in a short time.
I would be glad to either synthesize the polymers if you would send me the detailed protocol, or to receive the polymers from