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The Marshall W. Nirenberg Papers

Letter from Marshall W. Nirenberg to G. Schramm pdf (62,914 Bytes) transcript of pdf
Letter from Marshall W. Nirenberg to G. Schramm
In this letter to Dr. G. Schramm of the Max Planck Institute, Nirenberg requests information regarding the use of German-produced synthetic deoxypolynucleotides in his enzymatic investigations. Enclosing reprints of his previous articles, Nirenberg suggests that their collaboration could yield quick results in the study of protein synthesis crucial to deciphering the genetic code.
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1 (62,914 Bytes)
1961-11-22 (November 22, 1961)
Nirenberg, Marshall W.
Schramm, G.
Max-Planck-Institut fur Virusforschung
Reproduced with permission of Marshall W. Nirenberg.
Medical Subject Headings (MeSH):
RNA, Messenger
Exhibit Category:
Synthetic RNA and the Poly-U Experiments, 1959-1962
Box Number: 4
Folder Number: 30
Unique Identifier:
Accession Number:
Document Type:
Letters (correspondence)
Physical Condition:
Series: Series II: Correspondence, 1953-1993
Folder: General, 1953-1977
November 22, 1961
Dear Dr. Schramm:
I read your synthetic procedure for obtaining deoxypolynucleotides with great interest. I very much would like to get or make 2 to 5 mg of deoxypoly A, deoxypoly T, deoxypoly C, deoxypoly G, and also mixed polymers. I am interested primarily in cell-free protein synthesis from an enzymatic point of view. Recently we found that polyribo U served as a synthetic messenger RNA which directed the synthesis of polyphenylalanine in a cell-free system. I am enclosing reprints of this work which describe these experiments in detail. I would like to use the deoxypolynucleotides in this work for I feel certain that some will work in our enzymatic system. I would be glad to collaborate with you, if you would like to, on aspects of our work dealing with these polymers. Certainly they would have a great deal of potential in our cell-free system. Such a collaborative effort could yield important results in a short time.
I would be glad to either synthesize the polymers if you would send me the detailed protocol, or to receive the polymers from you.
Looking forward to hearing from you, I remain,
Sincerely yours,
Marshall W. Nirenberg
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