Approximation of Genetic Code Via Cell-Free Protein Synthesis Directed by Template RNA
This article offers a solution to the technical problems of a direct biochemical approach to deciphering the genetic code.
Comparison of the nucleotide sequence of a gene with the amino acid sequence of its corresponding protein remained problematic
as the sequence of nucleotides in each coding was initially unknown. The authors demonstrate with experimental evidence that
there are only a certain number of possible nucleotides per code word. Additionally, by using tobacco mosaic virus RNA to
direct the cell-free synthesis of a protein resembling TMV, the experiment suggests at least part of the genetic code appears
to be universal.
Item is a photocopy.
Number of Image Pages:
7 (996,648 Bytes)
Nirenberg, Marshall W.
Matthaei, J. Heinrich
Jones, Oliver W. Jr
Martin, Robert G.
Barondes, Samuel H.
Periodical: Nirenberg, Marshall W., J. Heinrich Matthaei, Oliver W. Jones Jr, Robert G. Martin, and Samuel H. Barondes. "Approximation
of Genetic Code Via Cell-Free Protein Synthesis Directed by Template RNA." Federation Proceedings 22, ([January-February
1963]): 55-61. Article. 7 Images.
Federation of American Societies for Experimental Biology
Reproduced with permission of the Federation of American Societies for Experimental Biology.
Medical Subject Headings (MeSH):
Translating the Code of Life and the Nobel Prize, 1962-1968