Morphine Receptors as Regulators of Adenylate Cyclase Activity
This article is an extension of earlier published work describing the neuroblastoma hybrid cell line and examining the effects
of morphine and other narcotics upon enzyme activity. The authors find that morphine and other narcotics inhibit enzyme activity
and that the inhibition is dependent upon morphine receptors. This leads to a hypothesis concerning the molecular basis for
narcotic addiction and tolerance at the end of the article.
Item is a photocopy.
Number of Image Pages:
5 (705,957 Bytes)
1975-02 (February 1975)
Sharma, Shail K.
Nirenberg, Marshall W.
Klee, Werner A.
Periodical: Sharma, Shail K., Marshall W. Nirenberg, and Werner A. Klee. "Morphine Receptors as Regulators of Adenylate Cyclase Activity."
Proceedings of the National Academy of Sciences of the United States of America 72, 2 (February 1975): 590-594. Article. 5
National Academy Press
Reproduced with permission of Marshall W. Nirenberg.
Medical Subject Headings (MeSH):
Tumor Cells, Cultured
Receptors, Opioid, mu
Neuroblastoma Research, 1967-1976
Dual Regulation of Adenylate Cyclase Accounts for Narcotic Dependence and Tolerance (August 1975)