Dual Regulation of Adenylate Cyclase Accounts for Narcotic Dependence and Tolerance
This article is an extension of the article titled, "Morphine Receptors as Regulators of Adenylate Cyclase Activity."
The dependence and tolerance phenomenon involving enzymes and morphine receptors is explained as follows: narcotics affect
enzymes in two opposing ways, each mediated by the opiate receptor. One process is responsible for the inhibition of the
enzyme by narcotics, the other is a compensatory increase in enzyme activity, which is delayed in onset and relatively stable.
Narcotics dependence and tolerance is the result of the positive regulation of the enzyme counteracting the inhibitory influence
of the morphine. Furthermore, the inhibitory and positive regulatory mechanisms provide a means for "activating and deactivating
neural circuits hours after the initial event and thus may play a role in memory process."
Item is a photocopy.
Number of Image Pages:
5 (740,043 Bytes)
1975-08 (August 1975)
Sharma, Shail K.
Klee, Werner A.
Nirenberg, Marshall W.
Periodical: Sharma, Shail K., Werner A. Klee, and Marshall W. Nirenberg. "Dual Regulation of Adenylate Cyclase Accounts for Narcotic
Dependence and Tolerance." Proceedings of the National Academy of Sciences of the United States of America 72, 8 (August
1975): 3092-3096. Article. 5 Images.
National Academy Press
Reproduced with permission of Marshall W. Nirenberg.
Medical Subject Headings (MeSH):
Receptors, Cell Surface
Neuroblastoma Research, 1967-1976
Morphine Receptors as Regulators of Adenylate Cyclase Activity (February 1975)