Tolerance and Dependence Evoked by an Endogenous Opiate Peptide
As part of an ongoing series of articles devoted to the topic, this article provides experimental evidence that the dual regulation
of enzyme production by narcotics accounts for the phenomenon of narcotic dependence and tolerance. Additionally, results
show that cells become tolerant and dependent on certain peptides, suggesting that "tolerance and dependence are normal
responses which regulate transynoptic communication" coupled to enzyme activity.
Item is a photocopy.
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3 (308,112 Bytes)
1976-09 (September 1976)
Nirenberg, Marshall W.
Klee, Werner A.
Periodical: Lampert, Arthur, Marshall W. Nirenberg, and Werner A. Klee. "Tolerance and Dependence Evoked by an Endogenous Opiate Peptide."
Proceedings of the National Academy of Sciences of the United States of America 73, 9 (September 1976): 3165-3167. Article.
National Academy Press
Reproduced with permission of Marshall W. Nirenberg.