Laboratory project: "Regulation of Receptor Activity"
Summary of work for this project as indicated on the report: "Evidence for a new type of PGE1 receptor coupled to cGMP
accumulation was obtained. Cell lines with PGE1 receptors coupled only to cAMP were found as well as cell lines with 2 species
of PGE1 receptors, one coupled to cAMP accumulation, the other to cGMP accumulation. The 2 species of PGE1 receptors also
desensitize at different rates. These results show that the coupling of PGE1 to increases in cAMP and cGMP levels are clonally
inherited properties which can be expressed independently."
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Number of Image Pages:
2 (116,911 Bytes)
1976-09 (September 1976)
Nirenberg, Marshall W.
National Heart and Lung Institute. Laboratory of Biochemical Genetics
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From Neuroblastoma to Homeobox Genes, 1976-1992
Neuroblastoma Research, 1967-1976
Annual Report of the Laboratory of Biochemical Genetics, October 1, 1975 - September 30, 1976 (September 1976)