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The Marshall W. Nirenberg Papers

Title:
Memorandum from Marshall W. Nirenberg to Claude Lenfant pdf (48,073 Bytes) transcript of pdf
Memorandum from Marshall W. Nirenberg to Claude Lenfant
Description:
This memorandum from Marshall Nirenberg to Claude Lenfant, Director of the National Heart, Lung and Blood Institute, lists the four major accomplishments of the Laboratory of Biochemical Genetics Laboratory during the period from 1978-1988.
Item is a photocopy.
Number of Image Pages:
1 (48,073 Bytes)
Date:
1988-08-22 (August 22, 1988)
Creator:
Nirenberg, Marshall W.
Recipient:
Lenfant, Claude
Rights:
This item is in the public domain. It may be used without permission.
Exhibit Category:
From Neuroblastoma to Homeobox Genes, 1976-1992
Box Number: 6
Folder Number: 32
Unique Identifier:
JJBBPL
Document Type:
Memorandums
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Series III: Laboratory Administration, [1959]-1993
SubSeries: Annual Reports, 1960-1993
Folder: Annual Reports, 1960-1988
Transcript:
Date: August 22, 1988
From: Marshall Nirenberg
Subject: Accomplishments of the Laboratory of Biochemical Genetics
To: Dr. Claude Lenfant
The major accomplishments of the Laboratory of Biochemical Genetics during the last ten years are as follows:
1. Demonstrated that treatment of neuroblastoma cells with cAMP results in increases in the abundance of some species of poly A+ RNA and the expression of voltage-sensitive ion channel proteins and other neuronal proteins that are required for synaptogenesis.
2. Elucidated the mechanism by which cellular metabolites regulate the activity of E. coli adenylate cyclase.
3. Demonstrated complex synergistic regulation of genes coding for enkephalin and neuropeptide Y by cAMP, glucocorticoids, activators of protein kinase C, and nerve growth factor.
4. Elucidated mechanisms involved in the formation, stabilization, and elimination of nicotinic acetylcholine receptor aggregates during the development of neuromuscular synapses.
Metadata Last Modified Date:
2010-09-20
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