Memorandum from Marshall W. Nirenberg to Claude Lenfant
This memorandum from Marshall Nirenberg to Claude Lenfant, Director of the National Heart, Lung and Blood Institute, lists
the four major accomplishments of the Laboratory of Biochemical Genetics Laboratory during the period from 1978-1988.
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1988-08-22 (August 22, 1988)
Nirenberg, Marshall W.
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Subject: Accomplishments of the Laboratory of Biochemical Genetics
To: Dr. Claude Lenfant
The major accomplishments of the Laboratory of Biochemical Genetics during the last ten years are as follows:
1. Demonstrated that treatment of neuroblastoma cells with cAMP results in increases in the abundance of some species of poly
A+ RNA and the expression of voltage-sensitive ion channel proteins and other neuronal proteins that are required for synaptogenesis.
2. Elucidated the mechanism by which cellular metabolites regulate the activity of E. coli adenylate cyclase.
3. Demonstrated complex synergistic regulation of genes coding for enkephalin and neuropeptide Y by cAMP, glucocorticoids,
activators of protein kinase C, and nerve growth factor.
4. Elucidated mechanisms involved in the formation, stabilization, and elimination of nicotinic acetylcholine receptor aggregates
during the development of neuromuscular synapses.