Skip to main contentU.S. National Library of MedicineU.S. National Library of Medicine

Profiles in Science
Pinterest badge Follow Profiles in Science on Pinterest!

The Marshall W. Nirenberg Papers

Letter from Haruhiro Higashida to Marshall W. Nirenberg pdf (71,304 Bytes) transcript of pdf
Letter from Haruhiro Higashida to Marshall W. Nirenberg
Higashida updates Nirenberg on his research project on hybrid cells at the University of Kanazawa School of Medicine in Japan. He provides Nirenberg with abstracts of work and data from experiments. This letter concludes with a request for more cells, qualified by the statement "these cells will only be used as a part of my own experiments."
Number of Image Pages:
1 (71,304 Bytes)
1988-04-08 (April 8, 1988)
Higashida, Haruhiro
University of Kanazawa. School of Medicine
Nirenberg, Marshall W.
Reproduced with permission of Haruhiro Higashida.
Exhibit Category:
From Neuroblastoma to Homeobox Genes, 1976-1992
Box Number: 5
Folder Number: 7
Unique Identifier:
Document Type:
Letters (correspondence)
Physical Condition:
Series: Series II: Correspondence, 1953-1993
Folder: General, 1978-1993
April 8, 1988
Dear Marshall:
I'm spending a very busy time, because every tasks are quite new to me as a laboratory head, though these are not distressful.
Unfortunately I haven't had an invitation letter from the Cold Spring Harbor Laboratory for this year's symposium on Molecular Biology on Signal Transduction, I have two abstracts in the meeting as a coauthor with S. Numa and D. Brown. Two abstracts are enclosed for your interest.
The research project on N x L hybrid cells are going well. The enclosed is a piece of data which shows the IP3(1,4,5) formation is a signal for ACh-induced hyperpolarization. We are planning to define which muscarinic subtype is present in these NL (308, 309, & 1F) hybrid cells.
As you know Toshi Nagastu has cloned the tyrosine hybroxylase gene, he is interested in seeing the gene expression of species-difference in clonal cell lines as well as different tissues. I've provided him N1E115 and NX31T cells which really have TH molecules in them (see enclosed photos). I remember that you said you have several adrenergic clones of chick retina and neuroblastomas (including N18-RE-105).
Please send me N18-RE-105 cells and if possible, one or two other retina hybrid cells in your list for TH-gene-expression experiments, under the understanding that these cells will only be used as a part of my own experiments participated.
With my best regards.
Sincerely yours,
Haruhiro Higashida
Metadata Last Modified Date:
Linked Data:
RDF/XML     JSON     JSON-LD     N3/Turtle     N-Triples