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The Victor A. McKusick Papers

Letter from James L. Reynolds to Victor A. McKusick pdf (73,636 Bytes) transcript of pdf
Letter from James L. Reynolds to Victor A. McKusick
Number of Image Pages:
1 (73,636 Bytes)
1971-04-21 (April 21, 1971)
Reynolds, James L.
Tulane University. School of Medicine
McKusick, Victor A.
Original Repository: Alan Mason Chesney Medical Archives. Victor Almon McKusick Collection
Reproduced with permission of James L. Reynolds.
Medical Subject Headings (MeSH):
Heart Defects, Congenital
Fetal Growth Retardation
Exhibit Category:
The Bar Harbor Course and "McKusick's Catalog," 1960-1980
Metadata Record Letter from James L. Reynolds to Victor A. McKusick (March 11, 1971) pdf (64,864 Bytes) transcript of pdf
Metadata Record Letter from Victor A. McKusick to James L. Reynolds (March 17, 1971) pdf (31,169 Bytes) transcript of pdf
Unique Identifier:
Document Type:
Letters (correspondence)
Physical Condition:
April 21, 1971
Dear Dr. McKusick:
Thank you for your letter of March 17th stating your wish that I present data on two topics: Heart Disease in Mongolism and Incidence of Heart Disease in Babies of Low Birth Weight. I also received the tentative program of the Fourth Conference on the Clinical Delineation of Birth Defects, June 7 to 11, 1971. The program looks very good. In a previous letter I tried to indicate that I was not happy with the data I had relative to heart disease in mongolism. I have since reviewed these data more carefully and am even more certain that I should not present them. The data are fragmentary and I do not believe that I have anything to add to the information already available. I would prefer not to present or publish on this topic.
I do believe the other topic, Congenital Cardiac Defects in Low-Birth-Weight, Full-term Babies, i.e. babies with intrauterine growth retardation, I.G.R., will be appropriate and of interest. Practically nothing has been reported on this topic. My prospective and retrospective study groups include a total of 451 children with congenital heart disease. Sixty-two of these (14%) had I.G.R. A variety of cardiac defects were found in these I.G.R. babies. The incidence of one defect, aortic stenosis, was, however, unusually high, 13%. This is in contrast to the 5.5% incidence of aortic stenosis found in those without I.G.R. The data suggests a possible relationship between I.G.R. and aortic stenosis.
Please let me know if this is satisfactory with you that I publish or present and publish only the congenital heart disease -- intrauterine growth retardation topic -- and not that of mongolism and heart disease. If you prefer that I not attend as a participant under these circumstances, I shall certainly understand.
With best regards,
Yours truly,
James L. Reynolds, M.D.
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