Letter from James L. Reynolds to Victor A. McKusick
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1971-04-21 (April 21, 1971)
Reynolds, James L.
Tulane University. School of Medicine
McKusick, Victor A.
Original Repository: Alan Mason Chesney Medical Archives. Victor Almon McKusick Collection
Reproduced with permission of James L. Reynolds.
Medical Subject Headings (MeSH):
Heart Defects, Congenital
Fetal Growth Retardation
The Bar Harbor Course and "McKusick's Catalog," 1960-1980
Letter from James L. Reynolds to Victor A. McKusick (March 11, 1971)
Letter from Victor A. McKusick to James L. Reynolds (March 17, 1971)
April 21, 1971
Dear Dr. McKusick:
Thank you for your letter of March 17th stating your wish that I present data on two topics: Heart Disease in Mongolism and
Incidence of Heart Disease in Babies of Low Birth Weight. I also received the tentative program of the Fourth Conference
on the Clinical Delineation of Birth Defects, June 7 to 11, 1971. The program looks very good. In a previous letter I tried
to indicate that I was not happy with the data I had relative to heart disease in mongolism. I have since reviewed these
data more carefully and am even more certain that I should not present them. The data are fragmentary and I do not believe
that I have anything to add to the information already available. I would prefer not to present or publish on this topic.
I do believe the other topic, Congenital Cardiac Defects in Low-Birth-Weight, Full-term Babies, i.e. babies with intrauterine
growth retardation, I.G.R., will be appropriate and of interest. Practically nothing has been reported on this topic. My
prospective and retrospective study groups include a total of 451 children with congenital heart disease. Sixty-two of these
(14%) had I.G.R. A variety of cardiac defects were found in these I.G.R. babies. The incidence of one defect, aortic stenosis,
was, however, unusually high, 13%. This is in contrast to the 5.5% incidence of aortic stenosis found in those without I.G.R.
The data suggests a possible relationship between I.G.R. and aortic stenosis.
Please let me know if this is satisfactory with you that I publish or present and publish only the congenital heart disease
-- intrauterine growth retardation topic -- and not that of mongolism and heart disease. If you prefer that I not attend
as a participant under these circumstances, I shall certainly understand.