Letter from James L. Reynolds to Victor A. McKusick
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1971-03-11 (March 11, 1971)
Reynolds, James L.
Tulane University. School of Medicine
McKusick, Victor A.
Original Repository: Alan Mason Chesney Medical Archives. Victor Almon McKusick Collection
Reproduced with permission of James L. Reynolds.
Medical Subject Headings (MeSH):
Heart Defects, Congenital
The Bar Harbor Course and "McKusick's Catalog," 1960-1980
Letter from Victor A. McKusick to James L. Reynolds (March 17, 1971)
Letter from James L. Reynolds to Victor A. McKusick (April 21, 1971)
March 11, 1971
Dear Dr. McKusick:
Thank you very much for your invitation to attend the Fourth Conference on Birth Defects. You suggested that I might speak
on heart disease in mongols. I can do this after getting our clinical and catheterization information together, but I do not
expect that anything original or very exciting will result from such an analysis. I believe we will find that mongols have
a high incidence of congenital heart disease, that a variety of defects are found, -- septal defects most frequently, that
there is perhaps a higher incidence of pulmonary vascular obstruction than in
non-mongoloid children, and that there may be evidence of alveolar hypoventilation and cor pulmonale as a complicating factor.
Others certainly have larger series, which can provide more comprehensive information, than ours.
I do have prospective and retrospective information about the incidence of intrauterine growth retardation in a large series
of children with congenital heart disease, and about the types of congenital cardiac defects encountered in these full-term,
low-birth-weight children. There is little, if any, information currently available about this. Perhaps you would find this
study more interesting.
After considering the above comments, please let me know if you think my presentation of either of these subjects, at the
meeting, would be of interest.