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The Christian B. Anfinsen Papers

Title:
Acceleration of Reactivation of Reduced Bovine Pancreatic Ribonuclease by a Microsomal System from Rat Liver pdf (1,308,970 Bytes) ocr (43,170 Bytes)
Acceleration of Reactivation of Reduced Bovine Pancreatic Ribonuclease by a Microsomal System from Rat Liver
Description:
Prior studies to this article by Anfinsen, Epstein, and Goldberger established that the time required for synthesizing a chain of protein such as ribonuclease in the tissues of higher organisms would be approximately two minutes. Here, the three researchers noted that an enzyme system in the endoplasmic reticulum of cells that catalyzed the disulfide interchange reaction and which, when added to solutions of reduced ribonuclease, catalyzed the rapid formation of the native disulfide pairing in a period less than two minutes. Subsequent studies would find that such motile proteins as staphylococcal nuclease or myoglobin could undergo virtually complete renaturation in only a few seconds or less.
Number of Image Pages:
8 (1,308,970 Bytes)
Date:
1963-02 (February 1963)
Creator:
Goldberger, Robert
Epstein, Charles
Anfinsen, Christian B.
Source:
Periodical: Goldberger, Robert, Charles Epstein, and Christian B. Anfinsen. "Acceleration of Reactivation of Reduced Bovine Pancreatic Ribonuclease by a Microsomal System from Rat Liver." Journal of Biological Chemistry 238, 2 (February 1963): 628-635. Article. 8 Images.
Publisher:
American Society for Biochemistry and Molecular Biology
Rights:
Reproduced with permission of the American Society for Biochemistry and Molecular Biology.
URL: http://www.jbc.org/Exit
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Subject:
Medical Subject Headings (MeSH):
Ribonucleases
Microsomes
Oxidation-Reduction
Enzymes
Research Design
Relation:
Metadata Record Purification and Properties of a Microsomal Enzyme System Catalyzing the Reactivation of Reduced Ribonuclease and Lysozyme (1964) pdf (857,512 Bytes) ocr (29,302 Bytes)
/ps/access/KKBBJY.pdf
Box Number: 27
Folder Number: 7
Unique Identifier:
KKBBJX
Document Type:
Articles
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Reprints and Research Publications, 1950-1993
SubSeries: Anfinsen Publications, 1954-1993
SubSubSeries: Numbered Reprints
Folder: 101-110
Metadata Last Modified Date:
2006-04-10
Linked Data:
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