The Amino Acid Sequence of an Extracellular Nuclease of Staphylococcus aureus: I. Linear Order of the Fragments Produced by
Cleavage with Cyanogen Bromide
Throughout the late 1960s, the primary concern of Anfinsen's laboratory was to understand the relationship between structure
and function in staphylococcal nuclease. Anfinsen chose to study this enzyme because it was relatively small, with only 149
amino acids, and because it appeared to be entirely dependent on noncovalent binding for the maintenance of an ordered catalytically
active structure. In this series of three articles, authored by Anfinsen and Taniuchi, but based primarily on research conducted
by the latter, the two scientists presented the first analysis of the primary sequence of the enzyme.
Number of Image Pages:
20 (3,476,213 Bytes)
1966-10-10 (October 10, 1966)
Anfinsen, Christian B.
Periodical: Taniuchi, Horoshi, and Christian B. Anfinsen. "The Amino Acid Sequence of an Extracellular Nuclease of Staphylococcus
aureus: I. Linear Order of the Fragments Produced by Cleavage with Cyanogen Bromide." Journal of Biological Chemistry
241, 19 (10 October 1966): 4366-4385. Article. 20 Images.
American Society for Biochemistry and Molecular Biology
Reproduced with permission of the American Society for Biochemistry and Molecular Biology.