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The Christian B. Anfinsen Papers

Title:
Fluorescence Studies of the Interaction of Nucleotides with the Active Site of the Nuclease of Staphylococcus aureus pdf (896,039 Bytes) ocr (23,927 Bytes)
Fluorescence Studies of the Interaction of Nucleotides with the Active Site of the Nuclease of Staphylococcus aureus
Description:
In the late 1960s, Anfinsen's lab sought to understand the complicated details of the physicochemical properties of Staphylococcus aureus in solution, ultimately to better understand the relationship of its structure to its function. In this article, Anfinsen, Cuatrecasas, and Edelhoch reported that the specific binding of a competitive inhibitor resulted in a marked decrease in tyrosyl fluorescence, which they interpreted as indicative of a specific interaction of the nucleotide with several tyrosyl groups in the active site of the enzyme.
Number of Image Pages:
8 (896,039 Bytes)
Date:
1967-11 (November 1967)
Creator:
Cuatrecasas, Pedro
Edelhoch, Harold
Anfinsen, Christian B.
Source:
Periodical: Cuatrecasas, Pedro, Harold Edelhoch, and Christian B. Anfinsen. "Fluorescence Studies of the Interaction of Nucleotides with the Active Site of the Nuclease of Staphylococcus aureus." Proceedings of the National Academy of Sciences of the United States of America 58, 5 (November 1967): 2043-2050. Article. 8 Images.
Publisher:
National Academy Press
Rights:
Reproduced with permission of Libby Anfinsen.
Subject:
Medical Subject Headings (MeSH):
Binding Sites
Ribonucleases
Deoxyribonucleases
Staphylococcus aureus
Research Design
Box Number: 27
Folder Number: 10
Unique Identifier:
KKBBKF
Document Type:
Articles
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Reprints and Research Publications, 1950-1993
SubSeries: Anfinsen Publications, 1954-1993
SubSubSeries: Numbered Reprints
Folder: 131-140
Metadata Last Modified Date:
2009-07-17
Linked Data:
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