Skip to main contentU.S. National Library of MedicineU.S. National Library of Medicine


Profiles in Science
   
Pinterest badge Follow Profiles in Science on Pinterest!

The Christian B. Anfinsen Papers

Title:
Amino Acid Residues Essential for Biological Activity of a Peptide Derived From a Major Histocompatibility Complex Class I Antigen pdf (691,995 Bytes) ocr (23,891 Bytes)
Amino Acid Residues Essential for Biological Activity of a Peptide Derived From a Major Histocompatibility Complex Class I Antigen
Description:
In this article, Anfinsen, in collaboration with a number of scientists at laboratories across the United States, reported his observations on the self interaction of peptides from the alpha-1 domain of the major histocampatibility complex (MHC) class I antigen. The authors noted that this self interaction, in the absence of cells and form aggregates that precipitate upon centrifugation, suggested that the biological effects in cells, which result from inhibition of receptor and transporter internalization, may be due to the binding of the peptide to the homologous sequences in the alpha-1 domain of the MHC class I molecule. The researchers suggested that MHC class I molecules, which function in the immune system to transport antigenic peptides to the cell surface, might also play a role in receptor recycling.
Number of Image Pages:
5 (691,995 Bytes)
Date:
1993
Creator:
Stagsted, Jan
Mapelli, Claudio
Meyers, Chester
Matthews, Brian W.
Anfinsen, Christian B.
Goldstein, Avram
Olsson, Lennart
Source:
Periodical: Stagsted, Jan, Claudio Mapelli, Chester Meyers, Brian W. Matthews, Christian B. Anfinsen, Avram Goldstein, and Lennart Olsson. "Amino Acid Residues Essential for Biological Activity of a Peptide Derived From a Major Histocompatibility Complex Class I Antigen." Proceedings of the National Academy of Sciences of the United States of America 90, (1993): 7686-7690. Article. 5 Images.
Publisher:
National Academy Press
Rights:
Reproduced with permission of the National Academy of Sciences (U.S.).
URL: http://www.pnas.org/Exit
   Disclaimer; please review our Privacy Policy
Subject:
Medical Subject Headings (MeSH):
Amino Acid Sequence
Protein Conformation
Histocompatibility
Peptides
Box Number: 28
Folder Number: 7
Unique Identifier:
KKBBKQ
Document Type:
Articles
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Reprints and Research Publications, 1950-1993
SubSeries: Anfinsen Publications, 1954-1993
SubSubSeries: Numbered Reprints
Folder: 221-230
Metadata Last Modified Date:
2017-07-10
Linked Data:
RDF/XML     JSON     JSON-LD     N3/Turtle     N-Triples