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The Christian B. Anfinsen Papers

Title:
Studies on the Structural Basis of Ribonuclease Activity pdf (247,597 Bytes) ocr (9,051 Bytes)
Studies on the Structural Basis of Ribonuclease Activity
Description:
This brief note was the product of Anfinsen's one-year postdoctoral fellowship from the Rockefeller Foundation at the Carlsberg Laboratory in Copenhagen. It was Anfinsen's second tour at the laboratory; his first in 1939-1940 was cut short due the outbreak of World War II. Working with the Danish biochemist Kaj Linderstrom-Lang and others, Anfinsen conducted an in-depth physical analysis of the structure of ribonuclease, or Rnase. The group suggested that only a relatively small part of the Rnase molecule, the "active center," is directly involved in catalytic activity, and therefore an ordered secondary structure in a protein was unnecessary for its properties as a catalyst. This conclusion was largely disproven by Anfinsen's subsequent research into amino acid sequencing and protein folding in the 1960s.
Item is a photocopy.
Number of Image Pages:
2 (247,597 Bytes)
Date:
1955
Creator:
Anfinsen, Christian B.
Harrington, William F.
Hvidt, Aase
Linderstrom-Lang, Kaj
Ottensen, Martin
Schellman, John
Source:
Periodical: Anfinsen, Christian B., William F. Harrington, Aase Hvidt, Kaj Linderstrom-Lang, Martin Ottensen, and John Schellman. "Studies on the Structural Basis of Ribonuclease Activity." Biochimica et Biophysica Acta 17, (1955): 141-142. Article. 2 Images.
Publisher:
Amsterdam Elsevier
Rights:
Reproduced with permission of Elsevier Science Publishers.
URL: http://www.elsevier.com/Exit
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Exhibit Category:
Protein Folding and the Thermodynamic Hypothesis, 1950-1962
Relation:
Metadata Record Commentary by Christian B. Anfinsen on 'Studies on the Structural Basis of Ribonuclease Activity' (1989) pdf (177,112 Bytes) ocr (4,994 Bytes)
/ps/access/KKBBKR.pdf
Metadata Record Letter from Christian B. Anfinsen to Bernard D. Davis (February 23, 1989) pdf (106,555 Bytes) transcript of pdf
/ps/access/KKBBHC.pdf
Box Number: 26
Folder Number: 15
Unique Identifier:
KKBBKW
Document Type:
Articles
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Reprints and Research Publications, 1950-1993
SubSeries: Anfinsen Publications, 1954-1993
SubSubSeries: Numbered Reprints
Folder: 45-50
Metadata Last Modified Date:
2010-12-13
Linked Data:
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