Studies on the Structural Basis of Ribonuclease Activity
This brief note was the product of Anfinsen's one-year postdoctoral fellowship from the Rockefeller Foundation at the
Carlsberg Laboratory in Copenhagen. It was Anfinsen's second tour at the laboratory; his first in 1939-1940 was cut short
due the outbreak of World War II. Working with the Danish biochemist Kaj Linderstrom-Lang and others, Anfinsen conducted
an in-depth physical analysis of the structure of ribonuclease, or Rnase. The group suggested that only a relatively small
part of the Rnase molecule, the "active center," is directly involved in catalytic activity, and therefore an ordered
secondary structure in a protein was unnecessary for its properties as a catalyst. This conclusion was largely disproven
by Anfinsen's subsequent research into amino acid sequencing and protein folding in the 1960s.
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Anfinsen, Christian B.
Harrington, William F.
Periodical: Anfinsen, Christian B., William F. Harrington, Aase Hvidt, Kaj Linderstrom-Lang, Martin Ottensen, and John Schellman. "Studies
on the Structural Basis of Ribonuclease Activity." Biochimica et Biophysica Acta 17, (1955): 141-142. Article. 2 Images.
Reproduced with permission of Elsevier Science Publishers.