Some Relationships of Structure to Function in Ribonuclease
This study by White and Anfinsen on the renaturation of fully denatured ribonuclease, or RNase, required subsequent supporting
investigations to establish what came to be called the "thermodynamic hypothesis." Here they reported that RNase
activity depended upon a variety of structural features, but noted that it could be inferred from the results of their experimentation
that only a small part of the enzyme molecule, what they termed the "active center," was necessary for catalyst.
Number of Image Pages:
9 (811,128 Bytes)
1959-09-04 (September 4, 1959)
White, F. H. Jr
Anfinsen, Christian B.
Periodical: White, F. H. Jr, and Christian B. Anfinsen. "Some Relationships of Structure to Function in Ribonuclease." Annals
of the New York Academy of Sciences 81, 3 (4 September 1959): 515-523. Article. 9 Images.
New York Academy of Sciences
Reproduced with permission of the New York Academy of Sciences.