Skip to main contentU.S. National Library of MedicineU.S. National Library of Medicine


Profiles in Science
   
Pinterest badge Follow Profiles in Science on Pinterest!

The Christian B. Anfinsen Papers

Title:
Solid Phase Synthesis of a 42-Residue Fragment of Staphylococcal Nuclease: Properties of a Semisynthetic Enzyme pdf (946,143 Bytes) ocr (25,088 Bytes)
Solid Phase Synthesis of a 42-Residue Fragment of Staphylococcal Nuclease: Properties of a Semisynthetic Enzyme
Description:
After discovering an error in their original primary sequence analysis of staphylococcal nuclease, in which residue 43 was misidentified as glutamine instead of glutamic acid, Ontjes and Anfinsen published this paper. They reported that a resynthesis of the correct sequence in turn yielded a product with high biological activity. Therefore, they concluded that residue 43, although not essential for folding, was very important for catalytic activity once folding had occurred.
Number of Image Pages:
8 (946,143 Bytes)
Date:
1969-10 (October 1969)
Creator:
Ontjes, David
Anfinsen, Christian B.
Source:
Periodical: Ontjes, David, and Christian B. Anfinsen. "Solid Phase Synthesis of a 42-Residue Fragment of Staphylococcal Nuclease: Properties of a Semisynthetic Enzyme." Proceedings of the National Academy of Sciences of the United States of America 64, 2 (October 1969): 428-435. Article. 8 Images.
Publisher:
National Academy Press
Rights:
Reproduced with permission of Libby Anfinsen.
Subject:
Medical Subject Headings (MeSH):
Amino Acid Sequence
Chromatography
Peptides
Relation:
Metadata Record The Synthesis of Protected Peptide Fragments of a Staphylococcal Nuclease (October 1967) pdf (666,740 Bytes) ocr (20,056 Bytes)
/ps/access/KKBBKD.pdf
Box Number: 27
Folder Number: 13
Unique Identifier:
KKBBLH
Document Type:
Articles
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Reprints and Research Publications, 1950-1993
SubSeries: Anfinsen Publications, 1954-1993
SubSubSeries: Numbered Reprints
Folder: 151-160
Metadata Last Modified Date:
2009-07-17
Linked Data:
RDF/XML     JSON     JSON-LD     N3/Turtle     N-Triples