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The Christian B. Anfinsen Papers

Title:
An Immunologic Approach to the Conformational Equilibria of Polypeptides pdf (840,868 Bytes) ocr (29,248 Bytes)
An Immunologic Approach to the Conformational Equilibria of Polypeptides
Description:
Certain antibodies are particularly well-suited for the study of the conformational equilibria of polypeptide fragments of nuclease in solution. Here, Anfinsen, Schechter, Sachs, and Eastlake hypothesized that such fragments actually existed in solution in conformational equilibrium, components of which were sufficiently similar to the native conformation that antibodies directed to the native molecule could bind. They were able to validate this hypothesis by using synthetic polypeptide fragments, which were already known to induce folding of complimentary fragments.
Number of Image Pages:
5 (840,868 Bytes)
Date:
1972-12 (December 1972)
Creator:
Sachs, David H.
Schechter, Alan N.
Eastlake, Ann
Anfinsen, Christian B.
Source:
Periodical: Sachs, David H., Alan N. Schechter, Ann Eastlake, and Christian B. Anfinsen. "An Immunologic Approach to the Conformational Equilibria of Polypeptides." Proceedings of the National Academy of Sciences of the United States of America 69, 12 (December 1972): 3790-3794. Article. 5 Images.
Publisher:
National Academy Press
Rights:
Reproduced with permission of Libby Anfinsen.
Subject:
Medical Subject Headings (MeSH):
Antigen-Antibody Reactions
Protein Conformation
Antibody Specificity
Epitopes
Box Number: 28
Folder Number: 4
Unique Identifier:
KKBBLL
Document Type:
Articles
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Reprints and Research Publications, 1950-1993
SubSeries: Anfinsen Publications, 1954-1993
SubSubSeries: Numbered Reprints
Folder: 191-200
Metadata Last Modified Date:
2009-07-20
Linked Data:
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