An Immunologic Approach to the Conformational Equilibria of Polypeptides
Certain antibodies are particularly well-suited for the study of the conformational equilibria of polypeptide fragments of
nuclease in solution. Here, Anfinsen, Schechter, Sachs, and Eastlake hypothesized that such fragments actually existed in
solution in conformational equilibrium, components of which were sufficiently similar to the native conformation that antibodies
directed to the native molecule could bind. They were able to validate this hypothesis by using synthetic polypeptide fragments,
which were already known to induce folding of complimentary fragments.
Number of Image Pages:
5 (840,868 Bytes)
1972-12 (December 1972)
Sachs, David H.
Schechter, Alan N.
Anfinsen, Christian B.
Periodical: Sachs, David H., Alan N. Schechter, Ann Eastlake, and Christian B. Anfinsen. "An Immunologic Approach to the Conformational
Equilibria of Polypeptides." Proceedings of the National Academy of Sciences of the United States of America 69, 12 (December
1972): 3790-3794. Article. 5 Images.