Franklin's relations with both Watson and Crick improved greatly once she moved from King's College to Birkbeck College,
and she was in regular contact with both as she worked on the structure of TMV. In this letter, Crick responded to some of
Franklin's recent findings and interpretations, and made suggestions about using the heavy-atom substitution technique
Item is handwritten.
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1954-11-12 (November 12, 1954)
Original Repository: Churchill Archives Centre. The Papers of Rosalind Franklin
Many thanks for your letter, and for the Fourier. It certainly "looks better". I am just a little worried that the
reversal of two terms of (as I remember) opposite signs can change the origin so much. This is presumably due to the Lorentz
factor bringing up the intensities [mathematical equation, see Lister Hill]. Do you think that you are getting any diffraction
effects? Perhaps an artificial temperature factor might help.
I agree with you about Caspar's interpretation, but feel the matter will really remain open until you either get a
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good picture of the protein lacking RNA, or with a good heavy atom (and even the latter may not make identification easy).
If you are to cope with complex phases you may have to think in terms of two heavy atoms at different places (like SH and
the pyromic [?] perhaps). That would be very exciting.
I don't know anybody off-hand for your ARC job, but I'll ask John Kendrew. In our experience it usually takes a little
time to find someone who is really suitable for that type of job.