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The Rosalind Franklin Papers

Title:
Letter from Francis Crick to Rosalind Franklin pdf (49,212 Bytes) transcript of pdf
Letter from Francis Crick to Rosalind Franklin
Description:
Franklin's relations with both Watson and Crick improved greatly once she moved from King's College to Birkbeck College, and she was in regular contact with both as she worked on the structure of TMV. In this letter, Crick responded to some of Franklin's recent findings and interpretations, and made suggestions about using the heavy-atom substitution technique on TMV.
Item is handwritten.
Number of Image Pages:
2 (49,212 Bytes)
Date:
1954-11-12 (November 12, 1954)
Creator:
Crick, Francis
Recipient:
Franklin, Rosalind
Source:
Original Repository: Churchill Archives Centre. The Papers of Rosalind Franklin
Rights:
Reproduced with permission of Odile Crick.
Subject:
Medical Subject Headings (MeSH):
Tobacco Mosaic Virus
RNA
Exhibit Category:
Envisioning Viruses: Birkbeck College, London, 1953-1958
Folder Number:
2/33
Unique Identifier:
KRBBBS
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Series: Work on Tobacco Mosaic Virus (TMV)
Folder: Correspondence Regarding Franklin's Research, 1953-1958
Transcript:
Friday, Nov. 12th '54
Dear Rosalind,
Many thanks for your letter, and for the Fourier. It certainly "looks better". I am just a little worried that the reversal of two terms of (as I remember) opposite signs can change the origin so much. This is presumably due to the Lorentz factor bringing up the intensities [mathematical equation, see Lister Hill]. Do you think that you are getting any diffraction effects? Perhaps an artificial temperature factor might help. I agree with you about Caspar's interpretation, but feel the matter will really remain open until you either get a
[END PAGE ONE]
[BEGIN PAGE TWO]
good picture of the protein lacking RNA, or with a good heavy atom (and even the latter may not make identification easy). If you are to cope with complex phases you may have to think in terms of two heavy atoms at different places (like SH and the pyromic [?] perhaps). That would be very exciting.
I don't know anybody off-hand for your ARC job, but I'll ask John Kendrew. In our experience it usually takes a little time to find someone who is really suitable for that type of job.
Come again.
Yours,
Francis
Metadata Last Modified Date:
2006-10-20
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