Skip to main contentU.S. National Library of MedicineU.S. National Library of Medicine

Profiles in Science
Pinterest badge Follow Profiles in Science on Pinterest!

The Rosalind Franklin Papers

Letter from Dorothy Wrinch to Rosalind Franklin pdf (952,520 Bytes) transcript of pdf
Letter from Dorothy Wrinch to Rosalind Franklin
Wrinch was a mathematician who had written extensively about the application of mathematics to interpreting molecular structure, including use of Fourier analysis for interpreting x-ray diffraction images of crystals. Franklin met her during her first visit to the U.S. in 1954, and they corresponded for several years about Franklin's crystallography work.
Number of Image Pages:
1 (952,520 Bytes)
1955-05-07 (May 7, 1955)
[Wrinch, Dorothy]
Franklin, Rosalind
Original Repository: Churchill Archives Centre. The Papers of Rosalind Franklin
Courtesy of the Churchill Archives Centre.
The National Library of Medicine's Profiles in Science program has made every effort to secure proper permissions for posting items on the web site. In this instance, however, it has either not been possible to identify or contact the current copyright owner. If you have information regarding the copyright owner, please contact us at
Medical Subject Headings (MeSH):
Tobacco Mosaic Virus
X-Ray Diffraction
Exhibit Category:
Envisioning Viruses: Birkbeck College, London, 1953-1958
Folder Number:
Unique Identifier:
Document Type:
Letters (correspondence)
Series: Work on Tobacco Mosaic Virus (TMV)
Folder: Correspondence Regarding Franklin's Research, 1953-1958
Dear Rosalind:
It was very generous of you to offer to send me a copy of the numerical entries from which your TMV cylindrical Patterson map was drawn. On reflexion, I would like very much to have this, if it is not troubling you too much. [Please say if F(000) is zero or? and the scale of the entries, even if only roughly known]. I have been wondering whether you find my confirmation of the idea of Bernal and Fan. that there is two-dimensional periodicity perpendicular to the x-axis . giving a hexagonal cell a= , or any other two-dimensional cell and whether, in particular, you agree with them in thinking that the strong 11A reflexions on l=2 are trigonally arranged about the axis? I ask this last question in particular because of the overall impression one gets from your figure 1 map in Nature 26Feb55 of the importance of the 10-11A reflexions on many different layer lines. Any information you feel willing to give me as to the presumed positions in three-dimensional space of such reflexions would interest me greatly.
I am very much interested in and also full of admiration for your remarkable work on NaDNA, as I mentioned in my last letter. The idea of having been able to get a three-dimensional Patterson map is extremely impressive. I stud the two sections in Nature 172,157,1953 with great interest and feel very curious as to what three-dimensional situation turns out to be responsible for the various remarkable features of the cylindrical Patterson , particularly of those features at z about 7A and rho = 8-14A and z about 2 1/2A and rho about 5 1/2A.
I do wish it were possible to discuss all these aspects of your beautiful work with you in conversation instead of in letters. Cant you spend some time with us at WoodsHole this summer, as my guest? We could, I think, give you a good time- and I hope no hurricane!
With best regards
Yours Dorothy W. May 7/55
Please excuse mess on other side. I only found I had already addressed this to Ms. Singer when I had written all this letter to you.
Metadata Last Modified Date:
Linked Data:
RDF/XML     JSON     JSON-LD     N3/Turtle     N-Triples