F. C. Bawden (1908-1971) was a pioneering plant pathologist and virologist based at the Rothamsted Experimental Station in
England. He and N. W. Pirie were longtime collaborators in plant virology. During 1956-57 Franklin's team studied a number
of different virus samples provided by Bawden, and elucidated their structures.
Number of Image Pages:
1 (81,758 Bytes)
1957-10-21 (October 21, 1957)
Bawden, F. C.
Rothamsted Experimental Station
Original Repository: Churchill Archives Centre. The Papers of Rosalind Franklin
Courtesy of the Churchill Archives Centre.
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Very many thanks for your letter and the curves showing the radial density distribution of the two forms of the cowpea strain
of tobacco mosaic virus. I was interested that you find the differences to be of the same magnitude as those between TMV
and CV4 because this is the kind of magnitude I have said there is between the two from serological behavior. Unfortunately
I have no CV4 or antiserum against CV4 so could not see whether the bean form of the cowpea virus is more closely related
serologically to CV4 than it is to TMV. If you have any CV4 perhaps you could send me a little and I would test it against
my antisera to the bean and tobacco forms of the cowpea virus.
There has been nothing published about chemical differences between these two forms but there is a good deal known. The bean
form, for instance, contains histidine, and the tobacco form does not, but I have not got full details of all the differences
that have been found. Markham got amino acid analyses done on the two forms, I think by M. W. Rees of the Biochemical Laboratory
in Cambridge. I gather he has no intention of publishing, but it would probably be worth your while to write to him and find
exactly what his results were. I have been intending to do this for some time, but have never got around to it, so I shall
be glad also to know what the results are. You might say you are writing at my suggestion and that any information would be
welcome to both of us.