Siegel was one of the researchers that Franklin met during her 1954 visit to the United States. In this letter, he describes
a sample of TMV he is sending her for x-ray diffraction analysis.
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1954-10-26 (October 26, 1954)
University of California, Los Angeles. College of Agriculture
Original Repository: Churchill Archives Centre. The Papers of Rosalind Franklin
Courtesy of the Churchill Archives Centre.
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It was indeed a pleasure to meet you on your recent visit to this country. You expressed a desire to examine some strains
of TMV which differ appreciably from the common strain. I am, therefore, sending you a sample of our U2 strain which differs
from the common strain in quite a number of properties, some of which are described in a paper which I am sending under separate
The sample consists of 10 cc containing 17 mg virus per cc. It is made up in 0.1 ionic strength cacodylic acid buffer which
is 0.08 M NaCl. You need only dialyze this solution through several changes of water in order to get rid of the salts, should
you so desire.
We would appreciate learning of any progress that you might make with this material. It would be interesting to find out
whether any of the differences that we have observed between strains is correlated with differences in the structure of the