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The Rosalind Franklin Papers

Letter from Albert Siegel to Rosalind Franklin pdf (60,175 Bytes) transcript of pdf
Letter from Albert Siegel to Rosalind Franklin
Siegel was one of the researchers that Franklin met during her 1954 visit to the United States. In this letter, he described another sample of TMV he was sending her for x-ray diffraction analysis.
Number of Image Pages:
1 (60,175 Bytes)
1955-02-23 (February 23, 1955)
Siegel, Albert
University of California, Los Angeles. College of Agriculture
Franklin, Rosalind
Original Repository: Churchill Archives Centre. The Papers of Rosalind Franklin
Courtesy of the Churchill Archives Centre.
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Medical Subject Headings (MeSH):
Tobacco Mosaic Virus
X-Ray Diffraction
Exhibit Category:
Envisioning Viruses: Birkbeck College, London, 1953-1958
Folder Number:
Unique Identifier:
Document Type:
Letters (correspondence)
Series: Work on Tobacco Mosaic Virus (TMV)
Folder: Correspondence Regarding Franklin's Research, 1953-1958
February 23, 1955
Dear Dr. Franklin:
Thank you for letting us know of your interesting results. The strain which you have is U2. We sent it to you as a 1.7 percent virus solution in 0.1 ionic strength cacodylate buffer.
I am sending you some of our common strain which is referred to in our publications as U1. It is also made up in cacodylic acid buffer and is at a concentration of 31 mg per cc. We prepare our virus solutions by differential centrifugation of a leaf grindate.
You will notice that the preparation of U1 that we have sent is murky brown in appearance. This is due to an adsorbed host nucleoprotein. Should you desire to work with a colorless preparation the adsorbed host nucleoprotein can be gotten rid of as described in the accompanying separate. None of the properties that we have examined appear to be different for the colored and colorless preparations, such as infectivity, electrophoretic mobility, UV sensitivity, UV absorption, etc.
We would very much be interested in hearing of any further progress that you make with this material.
Sincerely yours,
Albert Siegel
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