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The Rosalind Franklin Papers

Letter from H. Fraenkel-Conrat to Rosalind Franklin pdf (48,974 Bytes) transcript of pdf
Letter from H. Fraenkel-Conrat to Rosalind Franklin
Heinz Fraenkel-Conrat was one of many virus researchers that Franklin visited during her 1954 trip to the United States. Like many others, he was able to send her samples of the materials he was using. The TMV with heavy atoms, such as mercury, added would help Franklin calculate the structure of TMV more accurately. In this letter he responded to some of the x-ray diffraction findings she had sent him.
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1 (48,974 Bytes)
1956-03-14 (March 14, 1956)
Fraenkel-Conrat, H.
University of California, Berkeley
Franklin, Rosalind
Original Repository: Churchill Archives Centre. The Papers of Rosalind Franklin
Reproduced with permission of Ellen Singer-Vine.
Medical Subject Headings (MeSH):
Tobacco Mosaic Virus
X-Ray Diffraction
Exhibit Category:
Envisioning Viruses: Birkbeck College, London, 1953-1958
Folder Number:
Unique Identifier:
Document Type:
Letters (correspondence)
Series: Work on Tobacco Mosaic Virus (TMV)
Folder: Correspondence Relating to Franklin's First Visit to Berkeley, California, Mar. 1952 - Mar. 1958
March 14, 1956
Dear Dr. Franklin:
I have a bad conscience in not having answered your letter of January 7; this was in part due to my difficulty in digesting all the conflicting data. I had previously attributed the deficit in -SH groups (as indicated by several methods, one of which is Hg analysis) to autoxidative loss of the thiol, rather than as evidence for a subunit size appreciably different from 18,000. I still prefer this interpretation, really, because chemically all others are difficult to visualize and require bonds which have not yet been shown to exist in proteins.
Maybe in a year or two the various analyses and interpretations will again be in phase. Many thanks for sending the two M.S. I am preparing some more Hg-protein aggregate for you. Its behavior is rather complex, with a tendency to aggregate to an insoluble state at the slightest provocation. I do not yet know in what state it might be best to send it to you.
Sincerely yours,
H. Fraenkel-Conrat
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