Robley Williams was one of many virus researchers that Franklin visited during her 1954 trip to the United States. In this
letter, he brought her up to date on developments in his laboratory, which was working with reconstituted TMV.
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1955-10-10 (October 10, 1955)
University of California, Berkeley
Original Repository: Churchill Archives Centre. The Papers of Rosalind Franklin
Reproduced with permission of Robley C. Williams Jr.
I have spoken to Heinz Fraenkel-Conrat some time ago about sending you some reconstituted TMV, and I hope he has done so by
now. If not, the materials should soon be coming along.
Roger Hart has just found out, by way of a confirmation of the earlier work by H.F.C. and R.C.W., that his partially degraded
material (infectivity less than 10% of intact TMV) can be reactivated to almost full infectivity by simple mixture with TMV
protein. This type of reactivation has the advantage that there is no worry about possible contaminating virus in the RNA
preparation, a matter about which H.F.C. and R.C.W. have never felt completely sure. Hart works at higher levels of infectivity
where the risk of significant contamination in the protein fraction is negligible, and, of course, he uses no purified RNA.