The Rosalind Franklin Papers
- Notes on tobacco mosaic virus
- During her first few months at Birkbeck, Franklin submitted this informal memo regarding the direction her TMV research might
- Item is handwritten.
- Number of Image Pages:
- 2 (34,488 Bytes)
- 1953-05-18 (May 18, 1953)
- Franklin, Rosalind
- [Bernal, John Desmond]
- Original Repository: Churchill Archives Centre. The Papers of Rosalind Franklin
- Reproduced from the Franklin Collection at the Churchill Archives Centre with the permission of the copyright holder.
- Medical Subject Headings (MeSH):
- Tobacco Mosaic Virus
- Exhibit Category:
- Envisioning Viruses: Birkbeck College, London, 1953-1958
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- Unique Identifier:
- Document Type:
- Series: Work on Tobacco Mosaic Virus (TMV)
- Folder: Franklin File kept by Professor Bernal, Birkbeck College, 1953-1958
- Professor Bernal
- Here are the notes you asked me for, on both TMV and the coal problem. I hope this is what you wanted.
- [END PAGE ONE]
- [BEGIN PAGE TWO]
- T. M. V. products obtained by Prof. Jeemer (Brussels)
- TMV solutions contain a light fraction which can be separated by high speed centrifugation. (The light fraction contains 2
components of slightly different molecular weight).
- This substance possesses the immunological properties of TMV but contains no nucleic acid.
- Reducing the pH to 3.9 causes it to aggregate into rods of the same shape and size as TMV (shown by EM photographs). These
rods are subsequently stable at normal pH.
- It would therefore be interesting to make an X-ray study of the following substances: --
- 1 Normal TMV
- 2 The light fraction containing no RNA
- 3 Same as 2 aggregated into rods
- 4 RNA obtained in a high-molecular-weight form
- Ros Franklin
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