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The Rosalind Franklin Papers

Title:
Notes on tobacco mosaic virus pdf (34,488 Bytes) transcript of pdf
Notes on tobacco mosaic virus
Description:
During her first few months at Birkbeck, Franklin submitted this informal memo regarding the direction her TMV research might take.
Item is handwritten.
Number of Image Pages:
2 (34,488 Bytes)
Date:
1953-05-18 (May 18, 1953)
Creator:
Franklin, Rosalind
Recipient:
[Bernal, John Desmond]
Source:
Original Repository: Churchill Archives Centre. The Papers of Rosalind Franklin
Rights:
Reproduced from the Franklin Collection at the Churchill Archives Centre with the permission of the copyright holder.
Subject:
Medical Subject Headings (MeSH):
Tobacco Mosaic Virus
RNA
Exhibit Category:
Envisioning Viruses: Birkbeck College, London, 1953-1958
Folder Number:
2/31
Unique Identifier:
KRBBDQ
Document Type:
Notes
Memorandums
Language:
English
Format:
application/pdf
image/tif
Series: Work on Tobacco Mosaic Virus (TMV)
Folder: Franklin File kept by Professor Bernal, Birkbeck College, 1953-1958
Transcript:
Professor Bernal
Here are the notes you asked me for, on both TMV and the coal problem. I hope this is what you wanted.
R.E.F.
[END PAGE ONE]
[BEGIN PAGE TWO]
T. M. V. products obtained by Prof. Jeemer (Brussels)
TMV solutions contain a light fraction which can be separated by high speed centrifugation. (The light fraction contains 2 components of slightly different molecular weight).
This substance possesses the immunological properties of TMV but contains no nucleic acid.
Reducing the pH to 3.9 causes it to aggregate into rods of the same shape and size as TMV (shown by EM photographs). These rods are subsequently stable at normal pH.
It would therefore be interesting to make an X-ray study of the following substances: --
1 Normal TMV
2 The light fraction containing no RNA
3 Same as 2 aggregated into rods
4 RNA obtained in a high-molecular-weight form
Ros Franklin
18.5.53
Metadata Last Modified Date:
2010-05-28
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