Following her 1954 visit to the United States, Franklin collaborated with Commoner on a study of a protein he called B8, which
was similar to the protein in some viruses. Here she reported the submission and acceptance of their paper for publication
in Nature, and discussed work on materials obtained from other researchers.
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1955-04-27 (April 27, 1955)
Washington University. Henry Shaw School of Botany
Original Repository: Churchill Archives Centre. The Papers of Rosalind Franklin
Reproduced from the Franklin Collection at the Churchill Archives Centre with the permission of the copyright holder.
Thank you for your letter. The paper has been accepted by "Nature", and will appear immediately following that of
Rich and Dunitz.
I should very much like to look at I8. I imagine it might be expected to resemble TMV rather closely in structure, so that
I should like, at the same time, to look at some of the TMV with which it is associated. Different strains of TMV show appreciable
differences in the X-ray diagram, which might well be of the same order of magnitude as the difference between one strain
and its associated I8. Do you do all your work on a single strain? Dr. Siegel, at Los Angeles, has sent me some of his U1
and U2 strains, which differ appreciably, the former being rather like the strain I originally had from Pirie. Might a difference
of strain account for any of the difference between your preparation and Neumark's?
I have just received some "Protein A" from Schramm. I have not yet obtained any X-ray photographs, but the optical
properties confirm the positive contribution of the RNA. It is, in solution, positive and much more highly birefringent than
B8, and when dry is weakly negative. But birefringence in the gel state, of the second batch of B8 which you sent, was especially
low. The two gel specimens which I preserved from it, in fine capillaries, now show regions of positive, regions of negative
and regions of zero birefringence, all mixed up with one another. The orientation is quite definite, though not good.
I should like very much to have a written summary of your thoughts on these questions, as you suggest.