Skip to main contentU.S. National Library of MedicineU.S. National Library of Medicine

Profiles in Science
Pinterest badge Follow Profiles in Science on Pinterest!

The Rosalind Franklin Papers

Letter from Rosalind Franklin to Barry Commoner pdf (88,327 Bytes) transcript of pdf
Letter from Rosalind Franklin to Barry Commoner
Following her 1954 visit to the United States, Franklin collaborated with Commoner on a study of a protein he called B8, which was similar to the protein in some viruses. Here she reported the submission and acceptance of their paper for publication in Nature, and discussed work on materials obtained from other researchers.
Number of Image Pages:
2 (88,327 Bytes)
1955-04-27 (April 27, 1955)
Franklin, Rosalind
Commoner, Barry
Washington University. Henry Shaw School of Botany
Original Repository: Churchill Archives Centre. The Papers of Rosalind Franklin
Reproduced from the Franklin Collection at the Churchill Archives Centre with the permission of the copyright holder.
Medical Subject Headings (MeSH):
Tobacco Mosaic Virus
Exhibit Category:
Envisioning Viruses: Birkbeck College, London, 1953-1958
Metadata Record Letter from Rosalind Franklin to Barry Commoner (March 25, 1955) pdf (86,309 Bytes) transcript of pdf
Folder Number:
Unique Identifier:
Document Type:
Letters (correspondence)
Series: Work on Tobacco Mosaic Virus (TMV)
Folder: Correspondence Regarding Franklin's Research, 1953-1958
27th April, 1955.
Thank you for your letter. The paper has been accepted by "Nature", and will appear immediately following that of Rich and Dunitz.
I should very much like to look at I8. I imagine it might be expected to resemble TMV rather closely in structure, so that I should like, at the same time, to look at some of the TMV with which it is associated. Different strains of TMV show appreciable differences in the X-ray diagram, which might well be of the same order of magnitude as the difference between one strain and its associated I8. Do you do all your work on a single strain? Dr. Siegel, at Los Angeles, has sent me some of his U1 and U2 strains, which differ appreciably, the former being rather like the strain I originally had from Pirie. Might a difference of strain account for any of the difference between your preparation and Neumark's?
I have just received some "Protein A" from Schramm. I have not yet obtained any X-ray photographs, but the optical properties confirm the positive contribution of the RNA. It is, in solution, positive and much more highly birefringent than B8, and when dry is weakly negative. But birefringence in the gel state, of the second batch of B8 which you sent, was especially low. The two gel specimens which I preserved from it, in fine capillaries, now show regions of positive, regions of negative and regions of zero birefringence, all mixed up with one another. The orientation is quite definite, though not good.
I should like very much to have a written summary of your thoughts on these questions, as you suggest.
I will order the 100 reprints for you.
Yours sincerely,
Rosalind Franklin.
Metadata Last Modified Date:
Linked Data:
RDF/XML     JSON     JSON-LD     N3/Turtle     N-Triples