Letter from Rosalind Franklin to H. Fraenkel-Conrat
During her 1954 visit to the United States, Franklin met or renewed acquaintance with many virus researchers, who were able
to send samples of their virus material and brainstorm with her on her x-ray diffraction findings. Heinz Fraenkel-Conrat at
the UC Berkeley Virus Laboratory was especially helpful, sending a variety of heavy-atom substituted TMV preparations. In
this letter, Franklin, with her characteristic attention to detail, asked him for a sample of the unsubstituted TMV for comparison
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1955-05-16 (May 16, 1955)
University of California, Berkeley
Original Repository: Churchill Archives Centre. The Papers of Rosalind Franklin
Reproduced from the Franklin Collection at the Churchill Archives Centre with the permission of the copyright holder.
Thank you very much for the new preparations which I have just received. I am particularly grateful for the mercury compound.
With these two it should at least be possible to find on what radius the sulfur lies.
It would, however, be desirable to compare them with the TMV from which they were prepared. I have recently done some work
on different strains of TMV and find differences in the X-ray diagram which are appreciable. I did eventually get a moderately
good photograph from the iodine preparation which you sent me before, but the difference between it and other photographs
was of the same order as the difference between strains. So I should be very grateful if you could send me a little of your
un-treated TMV for comparison.