Letter from Rosalind Franklin to H. Fraenkel-Conrat
During her 1954 visit to the United States, Franklin met or renewed acquaintance with many virus researchers, who were able
to send samples of their virus material and brainstorm with her on her x-ray diffraction findings. Heinz Fraenkel-Conrat at
the UC Berkeley Virus Laboratory was especially helpful, sending a variety of heavy-atom substituted TMV preparations. In
this letter she requested a different mercury-substituted TMV preparation, and some substituted A-protein.
Number of Image Pages:
1 (58,618 Bytes)
1955-09-15 (September 15, 1955)
University of California, Berkeley
Original Repository: Churchill Archives Centre. The Papers of Rosalind Franklin
Reproduced from the Franklin Collection at the Churchill Archives Centre with the permission of the copyright holder.
During the course of our discussions in Brussels you mentioned that it might be possible for you to send me some Hg-TMV which
had less tendency to gel, and in which the amount of Hg bound was known with greater precision. This would be extremely valuable
to us. I have now got quite good photographs from the Hg-TMV you sent, but before embarking on a lengthy quantitative study
of the diagrams it would be preferable to look at the better preparation.
Would it be possible to prepare polymerized A-protein with Hg on it? This would be even more useful than the Hg-TMV as far
as the investigation of the structure of the protein part is concerned. The equator of the A-protein diagram is so completely
different from that of normal TMV that knowledge of the TMV diagram cannot be used to determine the signs for A-protein.
Hg-A-protein would make it possible to bridge the gap.