Letter from Joshua Lederberg to Barbara McClintock
Lederberg thanked McClintock for her assistance and clarified one of the "premises" he had made an earlier letter.
Number of Image Pages:
1 (54,954 Bytes)
1948-11-12 (November 12, 1948)
Original Repository: American Philosophical Society. Library. Barbara McClintock Papers
Reproduced with permission of Joshua Lederberg.
Medical Subject Headings (MeSH):
Controlling Elements: Cold Spring Harbor, 1942-1967
Letter from Joshua Lederberg to Barbara McClintock (November 12, 1948) (in The Joshua Lederberg Papers)
Box Number: 1
Folder Number: 7
November 12, 1948.
I have just received your letter and scheme for the coli heterozygote. I haven't studied it yet in detail, but I hasten
to thank you for the effort that you must have put into it. I will certainly study it very thoroughly.
Unfortunately, I think that I may have misled you concerning one of the premises: II-3. "the type of crossover chromatids
recovered in the segregants are not the expected ones in that many unusual multiple crossover chromatids are represented."
I did emphasize that certain multiple-mutant types could be recovered from the heterozygotes, but they are elusive only with
respect to the techniques that were previously available, viz. selection for prototrophs. In fact, the multiple mutant types
are merely the complements of the prototrophs, techniques for the recovery of which had been worked out before. This restatement
does not, I think, alter the bases of your suggestions, but may require a somewhat simpler version.
Again, I want to thank you for your suggestions, and remain,