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The Barbara McClintock Papers

Title:
Letter from Joshua Lederberg to Barbara McClintock pdf (54,954 Bytes) transcript of pdf
Letter from Joshua Lederberg to Barbara McClintock
Description:
Lederberg thanked McClintock for her assistance and clarified one of the "premises" he had made an earlier letter.
Number of Image Pages:
1 (54,954 Bytes)
Date:
1948-11-12 (November 12, 1948)
Creator:
Lederberg, Joshua
Recipient:
McClintock, Barbara
Source:
Original Repository: American Philosophical Society. Library. Barbara McClintock Papers
Rights:
Reproduced with permission of Joshua Lederberg.
Subject:
Medical Subject Headings (MeSH):
Mutation
Exhibit Category:
Controlling Elements: Cold Spring Harbor, 1942-1967
Relation:
Metadata Record Letter from Joshua Lederberg to Barbara McClintock (November 12, 1948) (in The Joshua Lederberg Papers) pdf (65,140 Bytes) ocr (1,190 Bytes)
/ps/access/BBAAVQ.pdf
Box Number: 1
Folder Number: 7
Unique Identifier:
LLBBGL
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Transcript:
November 12, 1948.
Dear Barbara,
I have just received your letter and scheme for the coli heterozygote. I haven't studied it yet in detail, but I hasten to thank you for the effort that you must have put into it. I will certainly study it very thoroughly.
Unfortunately, I think that I may have misled you concerning one of the premises: II-3. "the type of crossover chromatids recovered in the segregants are not the expected ones in that many unusual multiple crossover chromatids are represented." I did emphasize that certain multiple-mutant types could be recovered from the heterozygotes, but they are elusive only with respect to the techniques that were previously available, viz. selection for prototrophs. In fact, the multiple mutant types are merely the complements of the prototrophs, techniques for the recovery of which had been worked out before. This restatement does not, I think, alter the bases of your suggestions, but may require a somewhat simpler version.
Again, I want to thank you for your suggestions, and remain,
Yours,
Joshua Lederberg
Metadata Last Modified Date:
2010-04-08
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