Original Repository: Oregon State University. Library. Ava Helen and Linus Pauling Papers
Reproduced with permission of the Ava Helen and Linus Pauling Papers. Oregon State University Library.
Medical Subject Headings (MeSH):
The Molecular Basis of Disease
8 February 1960
I am happy to see your letter, now that I have come back to the lab. Even such a simple matter as staying out on a ledge
on the face of a cliff for one night seems to be a strain -- my wife was, however, much more affected by a worry than I was
I had with me at the ranch a rough draft of a manuscript on a theory of general anesthesia, which I had hoped to get into
shape for publication. Now I shall soon get back to work on this problem, and I have already initiated some experimental
My theory is quite a detailed one. It involves the action of the anesthetic agent in stabilizing microcrystalline aggregates
of water molecules and other molecules. It has occurred to me that you may know about some work on the theory of general
anesthesia that has escaped my attention, and I am accordingly writing to ask you to tell me, and in particular to send me
reprints of your own published papers in this field, if they are still available. Do you know of any good theoretical work
on general anesthesia that has been published during the last ten years, since the Paris Colloquium?