Thanks for your inquiries for more information about the sarc gene. I am enclosing preprints of manuscripts soon to appear
in Journal of Molecular Biology and Nature; I hope these will prove useful. Unfortunately I cannot tell you much about what
promises to be the most interesting aspect -- namely the regulation of the sarc-like gene in uninfected avian cells. The
gene is transcribed in cells derived from methylcholathrene-induced tumors from quail, but the import of that observation
may be dampened by our finding transcription of the sarc gene in normal embryos from several birds and in cultured fibroblasts;
in addition, we have not yet been able to test the tumors from which the tumor cells derived. Perhaps the sarc gene is involved,
in some as yet unknown way, with normal growth and development and with malignancy as well. But such an extravagant claim
must await further surveys of cells and tissues for expression of the gene. It would, of course, also be nice to know what
the gene product is -- but this is totally unknown for either the viral or cellular sarc genes.
If you see Ptashne in person as well as on tape (O brave new world), give him my blessings. Let me know if I can be of further
help to you. Incidentally, I will probably be talking about this business at the Cell Biology meetings in Boston the 2nd
week in September. If you're in town then, I would be glad to bring you up to date.