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The Harold Varmus Papers

Title:
Letter from Peter Bentvelzen, Radiobiological Institute of the Organization for Health Research (The Netherlands) to Harold Varmus pdf (69,775 Bytes) transcript of pdf
Letter from Peter Bentvelzen, Radiobiological Institute of the Organization for Health Research (The Netherlands) to Harold Varmus
Number of Image Pages:
1 (69,775 Bytes)
Date:
1975-08-22 (August 22, 1975)
Creator:
[Bentvelzen, Peter]
Radiobiological Institute of the Organization for Health Research (The Netherlands)
Recipient:
Varmus, Harold
Source:
Original Repository: University of California, San Francisco. Archives and Special Collections. Harold E. Varmus Papers
Rights:
Courtesy of Harold Varmus.
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Subject:
Medical Subject Headings (MeSH):
Mammary Tumor Virus, Mouse
Exhibit Category:
Retroviruses and the Genetic Origins of Cancer, 1970-1993
Relation:
Metadata Record Letter from Harold Varmus to Peter Bentvelzen, Radiobiological Institute of the Organization for Health Research (The Netherlands) (September 9, 1975) pdf (61,279 Bytes) transcript of pdf
/ps/access/MVBBCL.pdf
Box Number: 1
Folder Number: 6
Unique Identifier:
MVBBCK
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: UCSF Collections
SubSeries: Collection Number MSS 84-25
SubSubSeries: Correspondence, 1971-1984
Folder: Correspondence, 1975
Transcript:
Rijswijk, 22 August 1975
Dear Harold,
The BALB/c line I sent you will get about 40 % mammary tumors when bred after 15 months average. In about 10 % of the tumors I found infectious MTV. In a considerably higher percentage of tumors we do find MTV-P28 with our new sensitive immunoassays. When we pass this virus in BALB/c it induces 100 % tumors at 6 months. The virus then behaves as a traditional milkfactor. If you want to have some mice of the line with passaged MTV-O I can send you them. [HANDWRITTEN NOTE: sent in milk for comp[?] assay] We also have a lot of tumors induced by this virus.
As you know we claim that we can induce MTV in normal kidney cell cultures by exposure to dexamethasone or DMSO. Most of our work was based on immunofluorescence and among other Hilgers cannot confirm this. We have, however, also EM data.
We have now found that supernatants of C3Hf kidney cultures treated with either drug induce tumors at 5 months in BALB/c mice. As you know C3Hf mice in vivo only release MTV-L, and therefore we are excited about this finding. Of course, I had an open mind for cell or virus contamination in the tissue culture lab, but I have found it now in three consecutive experiments. I regard contamination as a very remote possibility.
The review is almost finished. Thank you for your permission to quote your on the higher number of MTV-DNA copies in the GR.
With kind regards,
P. Bentvelzen
Metadata Last Modified Date:
2010-04-22
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