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The Harold Varmus Papers

Letter from Harold Varmus to Salvador E. Luria pdf (71,582 Bytes) transcript of pdf
Letter from Harold Varmus to Salvador E. Luria
Number of Image Pages:
1 (71,582 Bytes)
1975-10-21 (October 21, 1975)
Varmus, Harold
Luria, Salvador E.
Original Repository: University of California, San Francisco. Archives and Special Collections. Harold E. Varmus Papers
Reproduced with permission of Harold Varmus.
Medical Subject Headings (MeSH):
Financing, Organized
Avian Sarcoma Viruses
Mammary Tumor Virus, Mouse
Exhibit Category:
Retroviruses and the Genetic Origins of Cancer, 1970-1993
Box Number: 1
Folder Number: 6
Unique Identifier:
Document Type:
Letters (correspondence)
Physical Condition:
Series: UCSF Collections
SubSeries: Collection Number MSS 84-25
SubSubSeries: Correspondence, 1971-1984
Folder: Correspondence, 1975
October 21, 1975
Dear Dr. Luria:
I am sending you my most recant grant proposals to give you a relatively detailed (perhaps too detailed) description of my current research plans. The avian tumor virus proposal was submitted to the American Cancer Society this spring, and I have been unofficially informed that it will be funded at the requested level. The mammary tumor virus application was submitted to the National Institutes of Health last month; it requests five years support. In both cases, I am the principal investigator, and Mike is listed as a co-investigator. Conversely, I am a co-investigator, along with Drs. Levinson and Levintow, on his NIH grant.
If I should go to MIT, I would expect to split my time between avian and mouse mammary viruses (whereas now I devote about 10% of my time to mammary virus). I think the availability of good animal quarters, some mouse geneticists, and the medical resources of the Boston area might direct me to more biological approaches to the mammary tumor virus problem, but I cannot say at this point what those approaches might be. I think I would look upon the avian work as the "bread and butter" of the operation, and I would probably direct my energies particularly at the mechanism of integration and the mapping and expression of integrated provirus in permissive cells. This may, of course, mean that Bob Weinberg and I will be asking some similar questions of similar (though far from identical) viruses, but I have always viewed this as a healthy thing. I do not feel that the situation is (or need be) tense or meanly competitive; I would be sorry to think that it would jeopardize his promotion. If so, I would probably consider it a mistake to move, and MIT would probably be making a mistake by asking me to do so.
I trust we'll be able to get together to talk this over sometime in early November.
Best regards,
Harold E. Varmus, M. D.
Associate Professor
Department of Microbiology
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