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The Harold Varmus Papers

Letter from Harold Varmus to Edward Fritsch, McArdle Laboratory for Cancer Research pdf (71,490 Bytes) transcript of pdf
Letter from Harold Varmus to Edward Fritsch, McArdle Laboratory for Cancer Research
Number of Image Pages:
1 (71,490 Bytes)
1976-12-14 (December 14, 1976)
Varmus, Harold
Fritsch, Edward
McArdle Laboratory for Cancer Research
Original Repository: University of California, San Francisco. Archives and Special Collections. Harold E. Varmus Papers
Reproduced with permission of the Regents of the University of California.
Medical Subject Headings (MeSH):
DNA, Viral
Exhibit Category:
Retroviruses and the Genetic Origins of Cancer, 1970-1993
Box Number: 1
Folder Number: 9
Unique Identifier:
Document Type:
Letters (correspondence)
Physical Condition:
Series: UCSF Collections
SubSeries: Collection Number MSS 84-25
SubSubSeries: Correspondence, 1971-1984
Folder: Correspondence, 1976
December 14, 1976
Dear Ed:
I am sending you copies of Ram's paper, as you requested. I have almost finished a manuscript describing our experiments with stationary phase cells and with randomly growing cells infected in the presence of BUdR. The points of the paper are: (1) synthesis of viral DNA, particularly of plus strand DNA, is inhibited in stationary cells; (2) the length of minus strands in stationary cells is less than full length (the length of plus strands is also reduced); (3) replication of cellular DNA is required for integration of viral DNA in either cells released from Go or in randomly growing cells. Our data are consistent with the idea that completion of the viral DNA molecule requires factor(s) present in cellular S phase and that integration requires replication of cellular DNA simply because viral DNA must first be completed. However, we cannot as yet show that the factor(s) depleted in stationary cells are normally present only in S (as opposed to being present throughout the cell cycle of unstarved cells). Moreover, it is possible that integration required some structural alteration in cellular DNA, since the presence of soluble factors which permit completion of viral DNA should result in integration of viral DNA into unreplicatad cell DNA in cells which have not yet fully traversed S phase. All this is more fully discussed in the manuscript.
I would, of course, like to acknowledge your findings in the discussion and wonder if you would be willing to send me a synopsis of your findings thus far. I can then send you a copy of my finished version, so that you can approve my use of your "personal communication". I am currently planning to submit our manuscript to Cell. If you and Howard the circumstances to be appropriate, I would certainly be willing to consider the possibility of simultaneous publication in the same journal. If you have any interest in this, please let me know as soon as possible.
Best regards,
Harold E. Varmus, M.D.
Associate Professor
Department of Microbiology
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