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The Harold Varmus Papers

Title:
Letter from Harold Varmus to Philip Leder, Harvard Medical School pdf (46,162 Bytes) transcript of pdf
Letter from Harold Varmus to Philip Leder, Harvard Medical School
Number of Image Pages:
1 (46,162 Bytes)
Date:
1983-10-21 (October 21, 1983)
Creator:
Varmus, Harold
Recipient:
Leder, Philip
Harvard Medical School
Source:
Original Repository: University of California, San Francisco. Archives and Special Collections. Harold E. Varmus Papers
Rights:
Reproduced with permission of the Regents of the University of California.
Subject:
Medical Subject Headings (MeSH):
Mutation
Exhibit Category:
Retroviruses and the Genetic Origins of Cancer, 1970-1993
Box Number: 2
Folder Number: 9
Unique Identifier:
MVBBGM
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: UCSF Collections
SubSeries: Collection Number MSS 84-25
SubSubSeries: Correspondence, 1971-1984
Folder: Correspondence, 1983
Transcript:
October 21, 1983
Dear Phil:
I thought you might be interested in the enclosed manuscript describing secondary mutations in the provirally-mutated c-myc alleles we have cloned from bursal lymphomas. I'd be curious to know whether you've encountered any somatic mutations in translocated c-myc alleles.
We are in the process of trying to work out some biological assay for these mutant alleles, using several cell types, including fresh bursal cells to be returned to chemically-bursectomized birds. In view of the obvious uncertainties, we are playing with all available technologies for getting DNA into lymphocytes; I appreciate the help we've gotten from Hunt Potter, whose electroshock method was mentioned to me by a graduate student formerly at Harvard. If and when we obtain anything interesting with this approach, I will let you know.
With best regards,
Harold E. Varmus, M.D.
Metadata Last Modified Date:
2008-09-23
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